Gilead Sciences, Inc.

Michael O' Neil Hanrahan Clarke

Richard L Mackman

Dustin S Siegel

Adrian S Ray

Robert Jordan

Edward Doerffler

William John Watkins

Scott E Lazerwith

Eda Y Canales

Hon Chung Hui

Jay P Parrish

Lee Shun Chong

Willard Lew

Byoung Kwon Chun

Jennifer R Zhang

Michael L Mitchell

Lianhong Xu

Dmitry Koltun

Eric Q Parkhill

Qi Liu

Michael R Mish

Ryan McFadden

Philip Anthony Morganelli

David Sperandio

Hai Yang

Gregory F Chin

Yunfeng Eric Hu

Xiaochun Han

Joy Yang Feng

Michael Mertzman

Tim Hansen

Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Methods for treatingvirus infections

The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

Imidazopyrimidine derivatives

Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1' position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

Methods for treating arenaviridae and coronaviridae virus infections

Provided are compounds of Formula I, as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.

2'-substituted carba-nucleoside analogs for antiviral treatment

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Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R, Rand Rare defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C. 

2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

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Redwood City, CA, United States of America

Michael O' Neil Hanrahan Clarke