Evolva Sa

Basf Se Corporation

Pna Diagnostics A/s

Michael Naesby

Jens Houghton-Larsen

Jorgen Hansen

Christophe Folly

Paula M Hicks

Simon Carlsen

Ernesto Simon

Fanny Delegrange

Thomas Oestergaard Tange

Thomas Tange Ostergaard

Esben Hansen Halkjaer

Sabina De Andrade Periera Tavares

Michael Mikkelsen Dalgaard

Oskar Zelder

Klaus Ditrich

Karsten Koerber

Michael Breuer

Stefan Haefner

Michael Dalgaard Mikkelsen

Holger Hartmann

Hartwig Schroeder

Joseph M Sheridan

Jonathan R Heal

Birgit Hoff

Markus Schwab

Curt Aimé Friis Nielsen

Niels Bjerg Jensen

Andrea Molt

Anaelle Hatsch

Neil Goldsmith

Sabina De Andrade Pereira Tavares

Beata Joanna Lehka

Walden Emil Bjørn-Yoshimoto

Patricia Hoyle

Michael Eichenberger

Ernesto Simón Vecilla

Alexandra M P Santana Sorensen

Soren V S Nielsen

Tange Thomas Ostergaard

Simon Ernesto

Hansen Esben Halkjaer

Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.

Biosynthesis of phenylpropanoids and phenylpropanoid derivatives

Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

Recombinant production of steviol glycosides

This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof.

Increased production of terpenes and terpenoids

The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.

Anthocyanins with specific properties

Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Genes and processes for the production of clavine-type alkaloids

In the present invention are disclosed concatemers of concatenated expression cassettes and vectors that enable the synthesis of such concatemers. The concatemer comprises in the 5'&#x2192;3&#x2032; direction a cassette of nucleotide sequence of the general formula [rs2-SP-PR-X-TR-SP-rs1]n wherein rs1 and rs2 together denote a functional restriction site, SP individually denotes a spacer of at least two nucleotide bases, PR denotes a promoter, capable of functioning in a cell, X denotes an expressible nucleotide sequence, TR denotes a terminator, and SP individually denotes a spacer of at least two nucleotide bases, and n&#x3e;/=2, and wherein at least a first cassette is different from a second cassette. The main purpose of these concatemers is the controllable and co-ordinated expression of large numbers of heterologous genes in a single host. Furthermore, the invention relates to a concatemer of cassettes of nucleotide sequences and a method for preparing the concatemers. In a further aspect, the invention relates to transgenic host cells comprising at least one concatemer according to the invention, as well as to a method for preparing the transgenic host cells. Finally, the invention relates to a vector comprising a cassette of nucleotides, a method for preparing said vector, a nucleotide library comprising at least two primary vectors each comprising a cassette of nucleotides, a method for preparing the library.

Concatemers of differentially expressed multiple genes

A method for the determination of nucleic acids which is highly specific and simple comprises the formation of a triple stranded binding complex including two separate, different probe molecules and detecting the formation of the complex via the inclusion of one of the probes. The method can be used to differentiate between nucleic acids having a single base difference in sequence.

Small triplex forming PNA oligos

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Basel, Switzerland

Michael Naesby