Sanofi Pasteur Vaxdesign Corporation

Vaxdesign Corporation

Michael N Nguyen

Robert Parkhill

William L Warren

Russell Higbee

Heather Fahlenkamp

Guzman Sanchez-Schmitz

Anatoly Kachurin

Donald Drake

David Moe

A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untitled configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.

Automated imaging and analysis of the hemagglutination inhibition assay (HAI)

A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untilted configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.

The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.

Methods for antibody production

Automatable artificial immune system (AIS)

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Orlando, FL, United States of America

Michael N Nguyen