Paratek Pharmaceuticals, Inc.

Boston University

Tufts University

Michael N Alekshun

Stuart B Levy

Brent L Podlogar

Roger Frechette

Mark L Nelson

Beena Bhatia

Todd Bowser

Tadeusz Warchol

S Ken Tanaka

Sean M Johnston

Kwasi Ohemeng

Mark Grier

Atul K Verma

Barbara A Seaton

Adel Bakhtyari

Masha Pukshansky

James F Head

Methods for increasing the oral bioavailability of tetracycline compounds are described.

Methods of increasing oral bioavailability of tetracyclines

Methods and compositions for the treatment ofinfections are described.

[object Object]

Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.

Methods for identifying and using MarR family polypeptide binding compounds

Disclosed are methods of treating bacterial infections including those caused by multidrug resistant bacteria using polyamine efflux pump inhibiting compounds, including for example N-benzylated polyazaalkanes, N-benzylated polyaminoalkanes, or mixed N-benzylated poly(aza/amino)alkanes, optionally in combination with other drugs such as antibiotics, as well as pharmaceutical compositions thereof.

Substituted polyamines as inhibitors of bacterial efflux pumps

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Transcription factor modulating compounds and methods of use thereof

The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in, and methods of crystallization of the MarR protein are described.

Crystals of MarR polypeptides, regulators of multiple antibiotic resistance

Growing community of inventors

Wakefield, MA, United States of America

Michael N Alekshun