Koch Engineering Company, Inc.

Sulzer Brothers Limited

Michael Mutsakis

Joseph P Porcelli

Chang-Li Hsieh

Friedrick Grosz-Roell

Dag O Calafell, Ii

Robert G Rader

A bioreactor, motionless mixing element with attached cells, and method for the enhanced cultivation and propagation of cells in a bioreactor method, and which bioreactor comprises a housing and contains within the housing a motionless mixing element, the attachment of cells to the mixing element and a nutrient composition permitting the cell growth and division of the attached cells, and which motionless mixing element and the method and bioreactor comprise a porous, fibrous sheet material; for example, of a corrugated or knitted, woven wire material, such as stainless steel or titanium, and of selected dimensions as to the fiber diameter and height, to provide a maximum surface area for the attachment of the cells to be cultivated, with the ratio of the fibrous, geometric surface area of the porous, fibrous sheet material to that of a sheet material of the same shape being greater than about 1.0; for example, 1.5, and typically, for example, having a surface area for cell growth of about 2000 to 3000 M.sup.2 /M.sup.3.

Bioreactor for culturing and propagating cells with a woven motionless

An improved laminar flow elbow system and method wherein the elbow system comprises a straight pre-pipe section to define the flow path of a fluid; the pipe section included directly prior to the inlet of a curved pipe section and having and comprising a plurality of vanes to impart a rotation to the fluid before passing through a curved pipe section to provide a generally flat velocity profile at the exit of the curved pipe section and to minimize turbulence of the fluid as it passes through the curved pipe section, and a substantially straight post-pipe section to define a flow path exit pipe section included directly at the exit of the curved pipe section, and containing a plurality of vanes to impart a backward rotation movement to the fluid flow from the exit of the curved pipe section, to substantially terminate rotation of the fluid upon exiting from the straight pipe section without substantial deterioration of the flatness of the fluid velocity profile and without generating substantial amounts of turbulence.

Laminar flow elbow system and method

Bioreactor method of culturing and propagating cells with a woven

A gas-liquid mass transfer apparatus and method, such as for the rapid heating of a liquid stream by a heated gas stream, such as steam, or the rapid dissolving of a gas stream into a liquid stream, which apparatus comprises: a housing having an axial flow path; static or motionless mixing elements disposed in the axial flow path; and passages in the housing to provide for the direct introduction of the gas stream into and about the liquid stream in the axial flow path and substantially along the length of the static mixing elements to provide a mixed product stream.

Gas-liquid mass transfer apparatus and method

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Brooklyn, NY, United States of America

Michael Mutsakis