Sandoz Gmbh

Novartis Ag

Michael Morris Dreyfuss

Hans Tscherter

Berndt Oberhauser

Carolyn Ann Foster

Theodor Fehr

Hans Hofmann

Maximilian Grassberger

Hans-Ulrich Naegeli

Max H Schreier

Gerhard Emmer

Dieter Geyl

Klaus Ruedi

Roy Ewald

Organic compounds

Cyclopeptolides

Pipecolic acid-containing peptolides wherein the peptidic backbone is of at least 9 .alpha.-amino acid residues joined together by peptide bonds, particularly the compounds of formula I ##STR1## wherein the substituents have various significances, are disclosed. They can be prepared by isolation or derivation from an appropriate microorganism strain such as S 42508/F (NRRL 15761). They have interesting pharmacological, e.g. antifungal, chemotherapeutic drug resistance reversing and to some extent immunosuppressant and antiinflammatory properties.

Pipecolic acid-containing peptolides, their preparation and

Cyclic peptolides having the structure of a cyclosporin in which one amide linkage is replaced by an ester linkage are obtained by fermentation of fungal strains of the genus Cylindrotrichum Bonorden, or by cyclization of a hydroxy-undecapeptide. The cyclic peptolides have immunosuppressive, anti-inflammatory and anti-parasitic properties.

Cyclosporin peptolides having an .alpha.-hydroxycarboxylic acid at

The compound of formula I ##STR1## known as S 39163/F-I which is effective e.g. as an antimicrobial and against herpes viruses.

Antibiotic lactone compound

This invention provides S 31794/F-1 which is a useful anti-mycotic for combatting Candida albicans infections.

Antibiotic S 31794/F-1

Growing community of inventors

Basel, Switzerland

Michael Morris Dreyfuss