Sangamo Biosciences, Inc.

Gendaq Limited

Sangamo Therapeutics, Inc.

Michael Moore

Yen Choo

Fyodor Urnov

Trevor Collingwood

Alan P Wolffe

Timothy Farries

Aaron Klug

Mark Isalan

Christopher Graeme Ullman

John Girdlestone

Lindsey Reynolds

Christophe Demaison

Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.

Modulation of stem cells using zinc finger proteins

Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stems cells into the desired phenotype, propagating stem cells and/or facilitating cloning.

Disclosed herein are methods and compositions for modulating HIV infection by regulating expression of one or more receptors.

Modulation of HIV infection

We describe a method of producing a modified nucleic acid binding polypeptide, the method comprising the steps of: (a) providing a nucleic acid binding polypeptide comprising a plurality of nucleic acid binding modules; (b) selecting a first binding domain consisting of one or two contiguous nucleic acid binding modules; (c) selecting a second binding domain consisting of one or two contiguous nucleic acid binding modules; and (d) introducing a flexible linker sequence to link the first and second binding domains, the flexible linker sequence comprising five or more amino acid residues. Use of structured linkers, alone or in combination with flexible linkers, is also disclosed.

Methods and compositions for linking binding domains in nucleic acid binding proteins

Disclosed herein are methods and compositions for modulation of gene expression, with single-gene specificity, in a human-sized genome.

Engineered zinc finger proteins for regulation of gene expression

This invention relates to a method for producing a zinc finger nucleic acid binding protein comprising preparing a zinc finger protein according design rules, varying the protein at one or more positions, and selecting variants which bind to a target nucleic acid sequence by polysome display.

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London, United Kingdom

Michael Moore