Kent State University

Michael Model

Anatoly Khitrin

The invention relates to systems and methods for observing materials, such as living cells or organisms, wherein the systems and methods utilize a microscopy system having an illumination source and an objective lens. A specimen including a predetermined amount of a liquid medium and a predetermined amount of an extracellular strongly absorbing dye is positioned for observation using the microscopy system. The illumination of the specimen correlates to the spectral region around the peak of the dye absorbance for the dye used in the system, such that live cells and organisms appear in contrast over a dark background for observation.

Microscopic systems and methods for observation of living cells and organisms

An optical measurement system for obtaining information such as the absorption coefficient of a light-absorbing liquid, or a surface profile of an object immersed in a light-absorbing liquid having a known absorption coefficient. The system includes a light source that transmits light through the liquid, a detector that records an image of the light transmitted through the sample and a processor or other means adapted to analyze the intensity distribution found on the image to generate information about the sample.

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Chagrin Falls, OH, United States of America

Michael Model