Pegbio Co., Ltd.

Michael Min Xu

Yinghui Zhang

Xiaosu Luo

Wei Lv

Yongxiang Wang

Nian Gong

Lijie Zhang

Xiangjun Zhou

The present invention provides a composition comprising a GLP-1 receptor agonist and a glucagon receptor agonist and an application of the composition. More specifically, the present invention provides a pharmaceutical composition comprising a pharmaceutically effective amount of the GLP-1 receptor agonist and the glucagon receptor agonist, wherein the GLP-1 receptor agonist and the glucagon receptor agonist independently form a conjugate with a hydrophilic polymer, or the GLP-1 receptor agonist and the glucagon receptor agonist jointly form a conjugate with the hydrophilic polymer.

Composition comprising GLP-1 receptor agonist and glucagon receptor agonist and application thereof

The invention provides a novel Exendin variant and the Exendin variant conjugate conjugating polymer thereon, the pharmaceutical composition comprising them and use of them for treating diseases such as reducing blood glucose, treating diabetes, especially Type II diabetes. The invention also provides the use of Exendin conjugate for lowering body weight.

Exendin variant and conjugate thereof

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Jiangsu, China

Michael Min Xu