Merck + Co., Inc.

Michael Midler, Jr

Edward L Paul

Mauricio Futran

Jaanpyng Hsu

Edwin F Whittington

Shih-Hsie Pan

Paul D Liu

Edward Paul

Impinging fluid jet streams are used in a continuous crystallization process to achieve high intensity micromixing of fluids so as to form a homogeneous composition prior to the start of nucleation. This process permits direct crystallization of high surface area particles of high purity and stability.

Crystallization method to improve crystal structure and size

A process for preparing a highly stable water-in-oil type emulsion consisting of (a) a disperse aqueous phase; (b) a continuous oil phase containing isomannide monooleate emulsifier and a non-hydrated physiologically acceptable fatty acid metal salt. A particular use of the invention is the preparation of an emulsion adjuvant vaccine, wherein the vaccine is incorporated in the aqueous phase. The emulsion is prepared by mixing the aqueous and oil phases at a relatively low agitator speed, optionally cooling, increasing the speed of agitation to form an emulsion and optionally homogenizing the emulsion.

Process for preparing an emulsion

Crystals are grown in a column through which a supersaturated solution flows upwardly while large crystals having one dimension substantially greater than another dimension taken from the bottom of the column are fractured externally of the column and the fractured particles are returned to the upper end of the column where fines are separated from larger seed type particles.

Crystallization system and method using crystal fracturing external to a

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East Brunswick, NJ, United States of America

Michael Midler, Jr