G.d. Searle & Company

Glaxo Group Limited

Glaxosmithkline Intellectual Property Development Limited

Michael Menteith Hann

Harry John Wadsworth

Alan Naylor

David Middlemiss

Neil Anthony Pegg

Stephen Paul Watson

Brian Evans

Keith G McCullagh

Duncan Robert Armour

Gerard Martin Giblin

David K Donald

Xiao-Qing Lewell

Christopher Herring

Markus Alexander Queisser

John Saunders

Lewis Lee Brayshaw

Carlos Martinez Fleites

Maria Victoria Vinader

Tania Hubbard

Keith Graham Mccullagh

The invention relates to a method of controlling the level of a polypeptide sequence comprising administering a polypeptide sequence fused to a ubiquitin targeting protein which comprises a minimal degron structural motif. In particular, the polypeptide sequence comprises a chimeric antigen receptor therefore the present invention is useful in methods of cell and gene therapy where the activity of the chimeric antigen receptor needs to be controlled.

Targeted protein degradation

The present invention relates to piperidine derivatives of formula (I) ##STR1## wherein R.sup.1 is a C.sub.1-4 alkoxy group; R.sup.2 is ##STR2## R.sup.3 is a hydrogen or halogen atom; R.sup.4 and R.sup.5 may each independently represent a hydrogen or halogen atom, or a C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl group;

Piperidine derivatives

This invention relates to compounds of the formula ##STR1## wherein R.sub.1 represents lower alkyl, phenyl, or phenyl lower alkyl; R.sub.2 represents lower alkyl; and R.sub.5 represents lower alkyl. These compounds are useful as intermediates in the preparation of collagenase inhibiting compounds which are useful in the treatment of arthritis and are of the formula ##STR2## wherein R.sub.1 represents lower alkyl, phenyl or phenyl lower alkyl; R.sub.2 and R.sub.4 represent lower alkyl; and R.sub.3 represents lower alkyl, benzyloxyalkyl, alkoxybenzyl or benzyloxybenzyl wherein the oxyalkyl or alkoxy moiety contain 1 to 6 carbon atoms; and a, b, and c represent chiral centers with optional R or S stereochemistry.

Intermediate for thiol based collagenase inhibitors

This invention relates to compounds of the formula: ##STR1## wherein R.sub.1 represents lower alkyl, phenyl or phenyl lower alkyl;

Thiol based collagenase inhibitors

This invention encompasses novel carboxyalkyl peptide derivatives which are collagenase inhibitors.

Carboxylalkyl peptide derivatives

Carboxyalkyl peptide derivatives

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Stevenage, United Kingdom

Michael Menteith Hann