The General Hospital Corporation

Northeastern University

Michael McCormack

Robert W Redmond

Irene Emily Kochevar

William Gerald Austen, Jr

William G Austen

Michael Sotirios Malamas

Alexandros Makriyannis

Nikolai M Zvonok

Kumara Vadivel Subramanian

Kyle M Whitten

Jay Matthew West

Spiro Pavlopoulos

Irene E Kocheavar

Robert C Redmond

William Gerald Austen Jr

A system and a method of preventing or reducing stenosis in a subject is provided. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent ('TSSA') under conditions, including irradiation with light, sufficient to promote cross-linking of proteins within the vein.

Methods and systems for preventing or reducing stenosis in a subject receiving a graft

One aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; placing the resected anatomical vessel in a chamber; and allowing the tissue passivation agent to cross-link while the resected anatomical vessel is in the chamber.

Vessel treatment systems, methods, and kits

One aspect of the invention provides an apparatus including: a fluid-impermeable membrane configured to contain a fluid and be placed in the cavity; a light emitter provided within the membrane; and a fluid provided within the membrane, wherein the fluid scatters light emitted by the light emitter such that the intensity of the light is substantially uniform over the inner surface of the cavity proximal to the membrane.

Apparatus for tissue irradiation and methods and kits utilizing the same

A system and method for treating a tissue is provided. The treatment causes a tightening or lifting of tissue. The method includes delivering a photochemical agent through a depth of the tissue to distribute the photochemical agent adjacent proteins within the tissue and irradiating the tissue with an electromagnetic irradiation at a wavelength that activates the photochemical agent, causing a protein response that brings fibers of the tissue closer together in order to one of reduce tissue laxity and tighten the tissue. A kit is provided to facilitate the method.

Method and apparatus for tightening skin and other tissues

One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent ('TSSA') under conditions sufficient to promote cross-linking of proteins within the vein.

Methods for tissue passivation

A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA).

N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof

Methods of tissue passivation are described herein for use in preserving normal tissue architecture, reducing post-surgical inflammation, and reducing or preventing the development of pathogenic collagen bundles and adhesions following surgical procedures. Passivated tissues prepared in accordance with these methods are useful in a variety of therapies including, e.g., cardiac bypass surgery, hemodialysis, etc.

One aspect of the invention provides a vessel treatment system including: a housing defining at least one opening adapted and configured to receive an anatomical vessel; and a humidifier in communication with the housing, the humidifier adapted and configured to introduce humidity into the housing to prevent desiccation of the anatomical vessel. Another aspect of the invention provides a kit including: the vessel treatment system as described herein; and a passivation agent. Another aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; and placing the resected anatomical vessel in a humidified chamber while the tissue passivation agent cures.

A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA). The present technology is directed to compounds, compositions, and methods to inhibit N-acylethanolamine hydrolyzing acid amidase and to treat N-acylethanolamine hydrolyzing acid amidase mediated conditions in a subject. 

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Medford, MA, United States of America

Michael McCormack