Radius Pharmaceuticals, Inc.

Michael Markey

Alex Eberlin

Richard Edwards

Michael Paul Cruskie, Jr

Joshua Kyle Bolger

Jonathan Blake McKenzie

Pratik Sheth

Useful processes of preparation and intermediates useful for the preparation of Compound 1, a selective estrogen receptor alpha (ERα) modulator/degrader (SERM/SERD), having utility for the treatment of ER+ cancers including breast cancer are described.

Processes and compounds

Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.

Polymorphic forms of RAD1901-2HCL

A solid form of RAD1901-2HCl having an X-ray powder diffraction pattern comprising a peak, in terms of 2-theta, at 11.53 degrees 2&#x3b8;&#xb1;0.2 degrees 2&#x3b8;, and compositions, methods, and processes thereof.

Growing community of inventors

Northborough, MA, United States of America

Michael Markey