Texas Heart Institute

Aviara Pharmaceuticals, Inc.

Pfizer Corporation

Encysive Pharmaceuticals, Inc.

Michael M Savage

Ronald J Biediger

Robert V Market

Brandon M Young

Peter Vanderslice

Michele A Benish

William C Gundlach, Iv

Iv Gundlach C William

Jie Chen

Keith Allen Monk

Brian Dupre

Pedro Lory

Reginald L Tennyson

Eric C Anderson

C William Gundlach

Reginald Tennyson

Iv C William Gundlach

Iv William C Gundlach

Provided herein are methods for antagonizing the action of an &#x3b1;4-integrin to treat various pathophysiological conditions utilizing pharmaceutical compositions of compounds or pharmaceutically acceptable salts or stereoisomer(s) thereof of formula I where R, R, R, R, R, X and Rare as described herein.

Propionic acid derivatives and methods of use thereof

A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein the integrin is selected from the group consisting of &#x3b1;4&#x3b2;1, &#x3b1;5&#x3b2;1, &#x3b1;4&#x3b2;7, &#x3b1;v&#x3b2;3 and &#x3b1;L&#x3b2;2, and contacting the treated cells with an integrin-binding ligand; integrin agonist compounds having the general formula I; methods of treating integrin-expressing cells with such agonists to enhance binding; and therapeutic methods comprising administering agonist-treated cells or agonist compounds to a mammal.

Agonists that enhance binding of integrin-expressing cells to integrin receptors

Provided herein are compounds and pharmaceutical compositions of formula I where R, R, R, R, R, X and Rare as described herein. Also provided pharmaceutically acceptable salts or stereoisomer(s) of these compounds. In addition methods are provided for antagonizing the action of an &#x3b1;4-integrin to treat various pathophysiological conditions.

Agonists that enhanced binding of integrin-expressing cells to integrin receptors

Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated with modulation of CCR9 receptor activity.

Modulators of CCR9 receptor and methods of use thereof

Growing community of inventors

Pearland, TX, United States of America

Michael M Savage