Scientific Learning Corporation

Other

Posit Science Corporation

University of California

The University of Texas System

Rutgers, the State University of New Jersey

Michael M Merzenich

Steven Lamont Miller

William Michael Jenkins

Paula Anne Tallal

Bret Edward Peterson

Christoph E Schreiner

Mor Nahum

Henry W Mahncke

Peter Brendan Delahunt

Chung-Hay Luk

Thomas Matthew Van Vleet

Srikantan Nagarajan

Joseph L Hardy

Athanassios Protopapas

Jyoti Mishra Ramanathan

Beverly A Wright

David T Blake, Jr

Donald Kelly Richards

Samuel Chungchi Chan

Wesley Marshall Jackson

Barbara Calhoun

Gerald E Loeb

Charles L Byers

Michael P Kilgard

Adam Gazzaley

Jefferson Arthur Dewey

Travis William Wade

Xiaoming Zhou

Gregory Michael Sabatini

Jyoti Mishra-Ramanathan

Stephen J Rebscher

Stephen G Lisberger

Etienne De Villers-Sidani

Hyun Kyu Lee

Dylan Hilmer Bird

Donald F Brenner

Nancy N Byl

Barbara M Calhoun

Nancy Byl

Merav Ahissar

Michael Scott Trujillo

Shaowen Bao

The present disclosure relates to methods and tools for enhancing cognition in an individual. The methods involve presenting to the individual multiple sets of stimuli. Each set of the multiple set contains two or more stimuli and at least one set of the multiple sets contains a target stimulus. The method then receives an input from the individual, and informs the individual as to whether the input is a correct response. The methods encompass iterations of stimuli presentation, receiving of the input, and lastly, generation of feedback to the individual until the individual learns and retains what the target stimulus is.

Method of suppressing of irrelevant stimuli

Provided are methods and tools for enhancing cognition in an individual. The methods involve presenting to the individual multiple sets of stimuli. Each set of the multiple set contains two or more stimuli and at least one set of the multiple sets contains a target stimulus. The method then receives an input from the individual, and informs the individual as to whether the input is a correct response. The methods encompass iterations of stimuli presentation, receiving of the input, and lastly, generation of feedback to the individual until the individual learns and retains what the target stimulus is.

A training program is configured to systematically drive neurological changes to treat depression, mood and anxiety disorders. The training program includes an inference renormalization game that presents three subsets of stimuli and prompts a game participant to selectively respond or withhold responding to one or two of the stimulus subsets.

Neuroplasticity games for depression

A game delivery system delivers a plurality of games in a training program. The training program is configured to systematically drive neurological changes to overcome cognitive deficits associated with a neurological disorder. In one embodiment, the training program includes an initial batch of games that predominantly exercise elemental, lower-level cognitive processes and sensory deficits. After a game participant progresses through the initial batch of games, the training program provides games that impose comparatively greater higher-order cognitive processing requirements on the participant. A clinician portal provides remote access to a clinician to data about the game participant's compliance and performance with the training program. The clinician portal also enables the administrator to configure the training program.

Neuroplasticity games

A training program is configured to systematically drive neurological changes to overcome social cognitive deficits. Various games challenge the participant to observe gaze directions in facial images, match faces from different angles, reconstruct face sequence, memorize social details about sequentially presented faces, identify smiling faces, find faces whose expression matches the target, identify emotions implicitly expressed by facial expressions, match pairs of similar facial expressions, match pairs of emotion clips and emotion labels, reconstruct sequences of emotion clips, identify emotional prosodies of progressively shorter sentences, match sentences with tags that identify emotional prosodies with which they are expressed, identify social scenarios that best explain emotions expressed in video clips, answer questions about social interactions in multi-segmented stories, choose expressions and associated prosodies that best describe how a person would sound in given social scenarios, and/or understand and interpret gradually more complex social scenes.

Neuroplasticity games for social cognition disorders

A training program is configured to systematically drive neurological changes to treat an addiction, wherein a plurality of addiction-related stimuli stimulate craving for the object of the addiction. The training program comprises at least one computerized reverse conditioning game configured to present a plurality of target and distractor stimuli, wherein the distractor stimuli are addiction-related stimuli, and prompts a game participant to respond to the target stimuli and ignore the distractor stimuli.

Neuroplasticity games for addiction

A new hearing profile assessment plays each of a plurality of frequency tones multiple times at a plurality of loudness levels. For each frequency, the patient indicates which tones that they can hear, establishing minimum-amplitude thresholds for each frequency. The assessment adapts loudness levels until the patient indicates consistent minimum-amplitude thresholds for each frequency. Also, a new system for training the hearing of a subject is disclosed. The system instructs the subject to vocalize various sound items and remember the sounds that they vocalize. The system plays either recorded samples of the subject's own voice, or comparison samples of a synthesized voice or other's vocalizations of the same sound items. The system prompts the subject to compare the played samples with the sounds they remembered vocalizing. The system uses the feedback to adjust sound processing parameters for a hearing aid, cochlear implant, sound output devices, or a training program.

Auditory perceptual systems

A training program is configured to systematically drive neurological changes to treat depression, mood and anxiety disorders. In one embodiment, a reward renormalization game presents a plurality of stimuli, a subset of which are positively affective, and the remainder of which are neutral or negatively affective, and prompts a game participant to respond to the positively affective stimuli and ignore the remainder of the stimuli. In another embodiment, an inference renormalization game presents a plurality of stimuli, a subset of which are positively affective, a second subset of which are negatively affective, and a third subset of which are neutral and prompts a game participant to respond to both the positively affective stimuli and the negatively affective stimuli and ignore the neutral stimuli.

A training program is configured to systematically drive neurological changes to treat an addiction, wherein a plurality of addiction-related stimuli stimulate craving for the object of the addiction. The training program comprises at least one computerized reverse conditioning game configured to present a plurality of target and distractor stimuli, wherein a subset of the distractor stimuli are addiction-related stimuli, and prompts a game participant to respond to the target stimuli and ignore the distractor stimuli.

A computer-implemented method for enhancing cognitive ability of an older participant by requiring the participant to differentiate between rapidly presented visual stimuli. First and second visual sweeps are provided for visual presentation to the participant, e.g., spatial frequency or orientation sweeps. At least two visual sweeps are visually presented to the participant utilizing the first visual sweep, the second visual sweep, or a combination. The participant is required to indicate an order in which the at least two visual sweeps were presented. A determination is made regarding whether the participant indicated the order of the visual sweeps correctly. The visually presenting, requiring, and determining are repeated one or more times in an iterative manner to improve the participant's cognition. The duration of the sweeps may be adjusted based on the correctness/incorrectness of the participant's response according to a maximum likelihood procedure. Assessments may be made during the exercise.

Cognitive training using visual sweeps

System and method for improving tactile sensitivity and precision/accuracy of motor control of the hand of a subject. A joystick is configured to provide commands to a computing device. The joystick includes a base, shaft, and a textured surface with a specified level of bumpiness. A computer-implemented exercise is executed, including presenting stimuli, including at least one target, to the subject via a computer display. The subject is required to respond to the stimuli via the joystick within a specified duration, including using the joystick to move a cursor to the target, and, upon reaching the target, disengage from the joystick. The subject's response to the stimuli is recorded, and a determination made regarding whether the subject responded correctly. The duration is modified based on whether the subject responded correctly to the stimuli. The presenting, requiring, recording, determining, and modifying are repeated a plurality of times in an iterative manner.

Joystick for training to improve sensory-guided fine motor control of the hand

Computer-implemented method for enhancing cognition of a participant using visual emphasis. One or more scenes are provided and are available for visual presentation to the participant, each scene having a background and at least one foreground object. A scene is visually presented to the participant with a specified visual emphasis that enhances visual distinction of the at least one foreground object with respect to the background, where the foreground object(s) and/or the background are modified or selected to achieve the specified visual emphasis. The participant is required to respond to the scene, and a determination made as to whether the participant responded correctly. The visual emphasis may be modified based on whether or not the participant responded correctly a specified number of times. The presenting, requiring, and determining (and possibly the modifying) are repeated in an iterative manner to improve the participant's cognition.

Visual emphasis for cognitive training exercises

Computer-implemented method for enhancing a participant's cognition, including, e.g., visual memory, utilizing a computing device to present visual stimuli for training, and to record responses from the participant. Multiple graphical elements are provided for visual presentation to the participant. A temporal sequence of a plurality of the graphical elements is visually presented, including displaying each graphical element in the sequence at a respective location in a visual field for a specified duration, then ceasing to display the graphical element. The presented graphical elements include at least two matching graphical elements. The participant is required to respond to the presented sequence, including indicating locations of matching graphical elements. A determination is made as to whether the participant responded correctly, and the duration modified based on the determining. The visually presenting, requiring, determining, and modifying are repeated one or more times in an iterative manner to improve the participant's cognition.

Cognitive training using guided eye movements

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San Francisco, CA, United States of America

Michael M Merzenich