Elobix Ab

Michael Lofthagen

Akinori Tatara

Ganapati Bhat

Johnson M Coutinho

Mikael Dahlström

Mikael Dahlstrom

Shinya Kiguchi

The present invention relates to a process for the preparation of a compound of formula (I) comprising: reacting a compound of formula (II) with a compound of formula (III) in the presence of a triazine compound to obtain a compound of formula (IV), and deprotecting said compound of formula (IV) to obtain the compound of formula (I). The compound of formula (I) can be prepared by the process according to the present invention in high yields and high purity. In addition, the process according to the present invention does not use a large amount of solvents or require a purification process of intermediate compounds.

Method for producing a 1,5-benzothiazepin compound

The present invention relates to a process for the preparation of certain 1,5-benzothiazepine compounds, and in particular to a process for the preparation of elobixibat. The process can be carried out under mild and safe conditions and may be used to prepare elobixibat on an industrial scale. The invention also relates to a process for the preparation of a crystalline monohydrate of elobixibat.

Process for the preparation of 1,5-benzothiazepine compounds

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Stockholm, Sweden

Michael Lofthagen