Otsuka Pharmaceutical Company, Limited

Other

Sitryx Therapeutics Limited

Michael Liam Cooke

David Cousin

Stuart Thomas Onions

Christopher William Murray

Valerio Berdini

Steven Howard

Ildiko Maria Buck

Alison Jo-Anne Woolford

Charlotte Mary Griffiths-Jones

Thomas Daniel Heightman

Jonathan Shannon

David Norton

James Edward Harvey Day

John Paul Watts

Marc O'Reilly

Matthew Colin Thor Fyfe

Stephen Thom

Finbar Gerald McDonnell

Saleh Ahmed

David Robert Bickham

Martin Reid Burton Davis

Samuel Duncan Housley

Andrew John Hinton

Thomas Michael Waugh

Barry John Teobald

Alessio De Simone

Jonathan Martin Shannon

The invention relates to compounds of formula (I): wherein A, R, R, R, Rand Rare as defined herein, and associated aspects.

Alpha, beta unsaturated methacrylic esters with anti-inflammatory properties

The invention relates to compounds of formula (IW-1) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein R, R, Rand Rare as defined herein.

Itaconic acid derivatives and uses thereof intreating an inflammatory disease or a disease associated with an undesirable immune response

The invention provides a compound of formula (0): The compounds are inhibitors of ERK1/2 kinases and will be useful in the treatment of ERK1/2-mediated conditions. The compounds are therefore useful in therapy, in particular in the treatment of cancer.

Benzolactam compounds as protein kinase inhibitors

The invention provides a compound of formula (0):  The compounds are inhibitors of ERK1/2 kinases and will be useful in the treatment of ERK1/2-mediated conditions. The compounds are therefore useful in therapy, in particular in the treatment of cancer.

A reactor for the oxidation of a precursor to an aromatic carboxylic acid or ester thereof in a liquid phase reaction mixture is disclosed. The reactor comprises an elongate vessel, substantially vertical in use, having an upper mixing element and a lower mixing element, characterised in that the upper mixing element is an axial pumping impeller and the lower mixing element is a radial pumping impeller. A process of producing a carboxylic acid or ester thereof in a reactor of the invention is also disclosed. In use, the configuration of mixing elements leads to three highly turbulent mixing zones. In a preferred embodiment of the process of the present invention oxidant, from one inlet, and solvent, precursor and catalyst, are introduced directly into a mixing zone. The highly turbulent mixing zones lead to rapid mass transfer suppressing the formation of unwanted, coloured by-products and reduced reactor fouling.

Apparatus for and method of producing aromatic carboxylic acids

A method and sensor for distinguishing between different optical isomers (enantiomers), which sensor comprises a pair of spaced-apart contacts and a semi-conductive polymer material spanning the gap between the contacts, which polymer material includes chiral sites. The chiral sites in the polymer material are preferably formed by incorporating an optically active counterion into the polymer material, for example by growing the polymer in the presence of such a counterion, e.g. camphor sulphonic acid.

Method and sensor for detecting volatile enantiomeric substances in gases

Growing community of inventors

Nottingham, United Kingdom

Michael Liam Cooke