Depuy Synthes Products, Inc.

Synthes Usa, LLC

Thermogenesis Corporation

Synthes Gmbh

Affinergy Inc.

Michael Lehmicke

Sean Hamilton Kerr

Mark T Fulmer

Ira C Ison

Bryan Monro Armitage

Patrick Leamy

William Schiffer

Philip H Coelho

Ross Hamel

Dominic D'Andrea

Christopher Shane

Jeff Kiersh

Elliott A Gruskin

Hanne Gron

Doug Buechter

John Maurice Marthaler

Kortney Wawrzyniak

Steven Paul Parmelee

David Duffin

Peter Kurzyna

Ira Ison

Brian Monroe Armitage

The present disclosure is directed to a method of preparing an osteogenic bone graft. The method includes introducing an anticoagulant compound into a volume of cellular material including a mononuclear cell population from the intramedullary canal of a long bone; collecting an effluent including the volume of cellular material containing the anticoagulant compound at a collection point; separating a concentrated cell fraction from the effluent, the concentrated cell fraction including the mononuclear cell population and the anticoagulant compound; and preparing an osteogenic bone graft from the concentrated cell fraction.

Method of preparing an osteogenic bone graft

A device for collecting a bone graft material comprises a canister extending defining a filter-receiving space therein, the canister including a connection for connecting to a vacuum source, a proximal end of the canister including a first locking feature and a filter element sized and shaped to be received within the filter-receiving space of the canister, the filter element including a channel extending therethrough, the channel defined via a mesh material and a proximal end of the filter element including a second locking feature releasably engageable with the first locking feature of the canister via a rotation of the filter element about a longitudinal axis thereof relative to the canister in combination with an extractor sized and shaped to be received within the channel of the filter element, the extractor defining a graft material receiving space therein and being releasably engageable with the extractor.

Graft filter with locking graft filter element and graft extractor

A bone marrow harvesting device includes a flexible bone marrow harvesting needle that can bend during operation to prevent the needle tip from piercing the inner cortical wall of the target bone. The needle defines an aspiration channel that defines an intake end that is recessed to reduce the instances that the aspiration channel will be fouled by bone particles or other debris within the cancellous portion.

Bone marrow harvesting device having flexible needle

The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.

Bone cement compositions having fiber-reinforcement and/or increased flowability

Compositions are provided comprising a family of peptides having binding specificity for bone, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to bone, and are used in methods related to bone implants, bone repair, and bone-related diseases.

Methods and compositions for promoting localization of pharmaceutically active agents to bone

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West Chester, PA, United States of America

Michael Lehmicke