Cirrex Systems, LLC

Cirrex Corp.

Other

Cell Precision, LLC

Visionex

Axsonus LLC

Graywire LLC

Michael L Wach

Eric Todd Marple

W Robert Taylor

Raymond P Vito

Dwight Holter

Jack C Griffis, Iii

Frank Lau

Jason Bourgeois

Jonathan L Shaw

Louis F Malice, Jr

Jack Griffis

Michael W Medin

Colleen Kraft

Gregory J Gervasio

Joseph T Dyer

To achieve in vivo repair of severed mammalian nerve tissue, a system can be employed to induce distraction neurogenesis. At least a portion of the system can be anchored at an injury site, such as between distal and proximal nerve ends. The system can be attached to the proximal nerve end and can place the nerve under micro-tension for an extended period of treatment. The system may also deliver medication or treatment to encourage neurogenesis and to reduce pain in the subject receiving treatment. After the course of treatment, the device can be removed from the injury site, and the nerve ends rejoined.

Method and system for distraction neurogenesis

Launching an aeronautical system can comprise applying force or energy to the system in connection with accelerating the system. Responsive to the force or energy, an element of the system can move along a defined path within the system. The system can comprise a drive that converts motion along the defined path into rotational motion. The drive can rotate a mass within the system, which can be supported by a gas bearing. The rotating mass can comprise the moving element, a different system element, or the entire system. The rotating mass can produce angular momentum and can support gyroscopic stabilization of the aeronautical system. Rotational energy can be selectively imparted to and transferred between system elements in connection with stabilization management. System elements can moderate the system's response to impulsive stimuli associated with rotation and acceleration. A gas bearing can support an external surface of the system during launch.

System and method for aeronautical stabilization

Systems, devices and methods are configured to prepare a specimen. A system may include a preparation device configured to mate with a specimen collection device. The preparation device may include an agitator member and a filter member. The filter member and the agitator member may be configured to move independently with respect to each other and the preparation platform member. The filter member may be configured to move linearly with respect to the preparation platform member and/or the agitator member, and the agitator member may be configured to move linearly and radially with respect to the preparation platform member and/or the agitator member. The system may also include a specimen collection device. The specimen may include but is not limited to fecal matter.

Systems, devices, and methods for specimen preparation

Delivery devices, systems, and methods are configured to enhance retention of a therapeutic agent delivered at a treatment site, for example, via impeding agent backflow. A device may include sheath having a first end, a second end, and a length between the first end and the second end. The sheath may include an outer diameter and an inner channel between the first end and the second end, and at least one penetrating member configured to form a channel at the treatment site. The device may include an elongate member having a first end, a second end, and a length between the first end and the second end, the elongate member being configured to move relative to the sheath. The elongate member may be configured to control the movement of the penetrating member with respect to the sheath.

Delivery devices, systems and methods for delivering therapeutic agents

A portable transfer board can facilitate moving a person having limited mobility, for example a person in a wheelchair transferring himself or herself into or out of a wheelchair. The portable transfer board can be transported in a compact configuration and placed in a transfer configuration on an as-needed basis. For example, a user or caregiver can tote the portable transfer board in a backpack, in a compartment on a wheelchair, or on his or her person. When needed for transfer, the user or caregiver can reconfigure the transfer board, so that at least one dimension is lengthened, and deploy the transfer board.

Portable transfer board and method

Optical waveguides can extend alongside one another in sufficient proximity such that light couples between or among them as crosstalk. The electromagnetic field associated with light flowing in one optical waveguide can extend to an adjacent optical waveguide and induce unwanted light flow. The optical waveguide receiving the crosstalk can comprise a phase shifting capability, such as a longitudinal variation in refractive index, situated between two waveguide lengths. Crosstalk coupled onto the first waveguide length can flow through the refractive index variation, be phase shifted, and then flow onto the second waveguide length. The phase shifted crosstalk flowing on the second waveguide can meet other crosstalk that has coupled directly onto the second waveguide segment. The phase difference between the two crosstalks can suppress crosstalk via destructive interference. Destructive interference can also result from disposing a phase shifting provision in a crosstalk coupling path located between two optical waveguides.

Isolating light paths

Two or more lasers or other temperature sensitive optical devices can be disposed in an operating environment, for example in a common enclosure exposed to the environment. The environment can have a temperature that fluctuates, for example in connection with random events, weather, seasons, etc. Each laser's temperature can track the temperature of the environment in steps, with each laser following a distinct temperature track. The lasers can alternate outputting light into a wavelength division multiplexing channel. For example, during one timeframe, one laser can provide an optical communication signal having a wavelength complying with a wavelength division multiplexing criterion. During another timeframe, the other laser can provide an optical signal having substantially the same wavelength. Operating a laser at an elevated temperature can shorten laser lifetime. To mitigate temperature induced failure, a replacement laser can be engaged when a failure predictor, precursor, or indicator meets a threshold.

Method and system for managing thermally sensitive optical devices

An interface between two different optical materials can comprise a stack of thin film layers that manage light incident on that interface. One of the optical materials can have a first composition and a first refractive index, while the other optical material can have a second composition and a second refractive index. The stack can comprise thin film layers of the first optical material interleaved between thin film layers of the second optical material. The layers of the stack can be configured to provide the stack with an aggregate composition of at least one of the optical materials that progressively varies from one end of the stack to the other end. To provide the progressive variation in composition, the layers of one of the optical materials can have a progressively increased thickness across the stack, or can progressively increase in number, for example.

Method and system for managing light at an optical interface

A stream of wavelength division multiplexed optical signals can be converted into the electrical domain and processed electrically to discriminate the information on each optical signal. An optical medium can transmit multiple optical communication signals, each having a different wavelength and each imprinted with different information. Detectors can receive the optical communication signals, with each detector receiving some of each communication signal. Thus, any one of the detectors can output an electrical signal according to a composite of multiple optical communication signals. Accordingly, each output electrical signal can include features or energy of each of the optical communication signals. An electrical circuit can process the electrical signals output by the detectors. The processing can remove from each electrical signal contributions from all but one of the optical communication signals, so that each processed electrical signal carries the information of a single wavelength division multiplexed optical signal.

System and method for receiving optical signals

An optical path can be created through optically challenging media. Light can transmit over the optical path between an end of an optical waveguide and a point displaced from the end. A fluid that scatters or absorbs light, generates interference, or otherwise poses optical challenges can be disposed between the waveguide end and the point. The optically challenging fluid can comprise blood, turbid and/or opaque fluid, absorbing liquids, or other liquid or fluid presenting transmission issues, for example. An optical path can be formed between the end and the point to facilitate transmitting light through the optically challenging fluid. In certain examples, the optical path can comprise a waveguide formed of fluids emitted into the optically challenging fluid, a gas injected into the optically challenging fluid, or an expandable structure, such as a balloon filled with substantially transparent liquid or gas.

Method and system for coupling light through challenging media

Light escaping from an optical path, for example via Raman or Rayleigh scattering, can provide information about how light flows in the path, about the optical path, or about matter disposed in the optical path. The path can be a waveguide, an optical channel, or a fiber that may be attached to or integrated with a substrate, for example in a passive or active planar lightguide/lightwave circuit, photonic integrated circuit, semiconductor laser, or optoelectronic element. The escaped light can be color-shifted with respect to the primary light flowing along the path. The escaped light can leave the path at an angle that facilitates detection. Processing or analyzing the scattered light, for example with support of a computing device, can help evaluate the path and/or assess a light intensity pattern thereof, for example to aid design, engineering, testing, qualification, troubleshooting, inspection, manufacturing, etc.

Method and system for evaluating an optical device

A robustly stabilized communication laser can output a multimode optical signal remaining aligned to a coordinate of a dense wavelength division multiplexing ('DWDM') grid while responding to a fluctuating condition or random event, such as, without limitation, exposure to a temperature fluctuation, stray light, or contamination. Responsive to the fluctuating condition, energy can transfer among individual modes in a plurality of aligned longitudinal modes. Modes shifting towards a state of misalignment with the DWDM coordinate can attenuate, while modes shifting towards a state of alignment can gain energy. Fabrication processes and systems and light management, such as beam steering, epoxy scaffolds, spectral adjustments, mode matching, thermal expansion control, alignment technology, etc. can facilitate nano-scale control of device parameters and can support low-cost fabrication.

Robustly stabilizing laser systems

An optical waveguide can transmit multiple optical signals imprinted or encoded with different information, thereby increasing the waveguide's information carrying capability or bandwidth. Each optical signal can comprise multiple longitudinal modes that are energized and that are modulated substantially in unison. Thus, the photonic energy of each optical signal can be spread across a wavelength region in a substantially discrete or substantially discontinuous pattern. The respective wavelength regions of the optical signals can overlap or substantially overlay one another. Modes of one of the optical signals can be substantially interleaved, interspersed, or intermingled with modes of other optical signals. Systems at ends of the optical waveguide can feed the optical signals onto and off of the optical waveguide and discriminate the optical signals from one another. The systems can comprise ring resonators. The waveguide can support an on-chip network, such as for a multicore processor of a computer.

Method and system for multiplexing optical communication signals

An optical thin film can have a refractive index variation along a dimension that is perpendicular to its thickness. Two areas that have equal physical thicknesses can have different optical thicknesses. Including the thin film as a layer in a thin film optical filter can provide a corresponding variation in the filter's spectral properties. Dosing an optical thin film with ultraviolet light can cause the refractive index variation. Subjecting the film to hydrogen can increase the refractive index's response to the dose of light. Dosing a region of a thin film optical filter with ultraviolet light can change the spectral properties of the region, for example shifting an out-of-specification optical filter into specification thereby increasing manufacturing yield. An agent can promote the film's response to the dose.

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Alpharetta, GA, United States of America

Michael L Wach