Perkin-Elmer Corp., Applied Biosystems Division

Michael L Metzker

John S Shigeura

George Stefan Golda

John A Bridgham

Norman M Whiteley

Paul E Mayrand

Louis B Hoff

Lincoln J McBride

William J Mordan

Douglas H Keith

Thomas Brennan-Marquez

Melvyn N Kronick

Chen-Hanson Ting

Eric Lachenmeier

Marianne Hane

Harry A Guiremand

G Richard Cathcart

A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids.

Automated molecular biology laboratory

Growing community of inventors

San Bruno, CA, United States of America

Michael L Metzker