Smithkline Beecham Corporation

Oriel Therapeutics, Inc.

Glaxo Group Limited

International Business Machines Corporation

Rai Strategic Holdings, Inc.

Pearl Therapeutics, Inc.

Becton Dickinson and Company Limited

Troxler Electronic Laboratories, Inc.

Sensal Health, LLC

Spencer Health Solutions, LLC

Michael L King

Alan D Ball

James Taylor Lloyd

Jeffrey Alan Warden

Patrick David Lopath

Lawrence A Stone

John Peter Karidis

Michael F Davis

James William Rogers

Gerard McVicker

Percy D Phillips

Samuel A Lucente

William Kevin Carpenter

Owen Lewis Joyce

David A Clemens

Frederic P Ampolini

Sean M Ahr

Richard F Sapper

Robert Paul Tennant

Nicholas A Oxley

Matthew S Ferriter

Sarvajna Kumar Dwivedi

John W Denny

John Kim

Jill Sherwood

Michael Philip Goldowsky

Matthew P Daniels

Charles D Shermer

Kenneth G Powell

Jeremy Scott Bridges

Donald Kent McAlister

Steve Worm

Fred Hamlin

Denny Himel

Richard D LaRoche

Brian Foster

Benjamin Finney

Dan Deaton

Martin T Tucker

Robert V Sheehy, Jr

Mark I Perisich

Aubrey Lamond Hodges

Michael Richard Floyd

David Wilkinson

John T Eagan

Jacob D White

Eric X Bonpain

Jeffrey J Schedel

Paul Joseph Cunningham

Nestorius Wiegandt

Deepak Sirdeshmukh

Timothy Paul Hiteshew

Kenneth A High

Sasha Morris

Jeffery Alan Warden

Paul Andrew Hakenewerth

Michael J Kiplinger

Joseph F Lamoreux

John Michael Burton, Jr

M Todd Tucker

Jr Burton

George Raymond Abrams

Weldon Curl

Thomas P Rhoads

Richard D Laroche

John Michael Burton

Neal Dawes

David Christopherson

Scott Thomas Hackett

Brian Kerrigan

Dan Fuccella

Robert V Sheehy

Jr John Michael Burton

George Raymond Abrams Jr

Weldon Curl Jr

Thomas P Rhoads Jr

John Michael Burton Jr

Gerard Libby

Vipul Negi

Kyle Woodard

The present disclosure relates to aerosol delivery devices, methods of producing such devices, and elements of such devices. In some embodiments, the present disclosure provides devices configured for vaporization of an aerosol precursor composition that is contained in a reservoir and transported to a heating element by a liquid transport element. The liquid transport element may include a porous monolith.

Aerosol delivery device with a liquid transport element comprising a porous monolith and related method

Systems and methods for isolating and/or desiccating a portion of a drug delivery tract of a drug delivery apparatus to reduce water vapor content therein are provided. For example, there is provided a metered dose inhaler for delivering aerosolized medicament or other matter to a user. The aerosolized medicament or other matter may be discharged from a discharge passageway within the inhaler into an inhalation passageway for inhalation by a user, and the inhaler may comprise a seal member operative to selectively isolate the discharge passageway from the inhalation passageway and external environment during inactivity. The inhaler may further comprise a desiccant material arranged to withdraw moisture from the isolated discharge passageway. In other instances, desiccant material may be arranged to withdraw moisture from the discharge passageway of the inhaler without isolating the discharge passage during inactivity.

Drug delivery systems and related methods

Medication container dock

The present disclosure relates to aerosol delivery devices, elements of such devices, and methods for producing vapor. In some embodiments, the present disclosure provides devices configured for vaporization of an aerosol precursor composition that is contained in and transported to a heating element by a unitary reservoir and liquid transport element. The unitary reservoir and liquid transport element may include a porous monolith.

Aerosol delivery device with a unitary reservoir and liquid transport element comprising a porous monolith and related method

The present specification describes a system for automatically preparing medication cartridges for use in a pharmaceutical dispensing system. The system includes a spooler device that winds a strip of medicine pouches around a cylinder in a cartridge frame. When the cartridge has been loaded with the medication strip, the system validates that there is a match between the information on the cartridge cover and the mediation pouches.

System and method for loading a dispensing cassette useful in a system for dispensing pre-packaged pharmaceuticals

Dry powder inhalers include electronic displays, readers and/or counters that can decrement dose amounts, inhibit misuse, read data on drug containment devices and/or communicate with remote devices. The dry powder containers can include at least a pair of cooperating generally tubular members, including an inner member and a generally tubular outer member sized and configured to slidably receive the inner member.

Dry powder inhalers

Inhalers with fins that deagglomerate dry powder using inspiratory effort of a user of an inhaler. The inhaler fins, at least in steady state conditions, are configured to generate dry powder and airflow patterns having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path, as an amount of dry powder travels through the inhaler to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation.

Dry powder inhalers that inhibit agglomeration, related devices and methods

A device, system and method is provided for dispersing an aerosol formulation comprising a medicament. The device may be useful in administering inhaleable vaccines and the like. The device designed for low cost and applicability to a multitude of patient populations. The device has a spacer () is suitable for use with a wide range of aerosolized formulations, particularly powders. The spacer () may be an expandable volume spacer (). The spacer () may also be used with other inhalation aids (). The spacer () may include a multi-purpose outlet () for use with different groups within the target patient population.

Disposable spacer for inhalation delivery of aerosolized drugs and vaccines

Dry powder inhalers include: (a) a first generally planar spiral travel path in an inhaler body, wherein the first spiral travel path has a plurality of adjacent curvilinear channels forming lanes with upstanding sidewalls, including an inner lane and an outer lane; and (b) a plurality of discrete sealed microcartridges with substantially rigid bodies disposed in the first travel path, each comprising a pre-metered (typically dose) amount of dry powder, the microcartridges being configured to slidably advance along the first travel path toward an inhalation chamber that merges into an inhalation output port. In operation, at least one microcartridge is held in the inhalation chamber to release the dry powder therein during inhalation.

Methods of operating dry powder inhalers having spiral travel paths with microcartridges of dry powder

The disclosure describes methods and inhalers that deagglomerate dry powder using inspiratory effort of a user of an inhaler. Inhaler fin and mesh configurations are described that facilitate deagglomeration. At least in steady state conditions, a dry powder and airflow pattern can be generated having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path, as an amount of dry powder travels through the inhaler to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation.

Dry powder drug containment systems with a stick substrate and at least one dry powder receptacle or container that can be detached or opened to release dry powder in an inhaler. Related inhalers and kits of sticks are described.

Drug containment systems with sticks, related kits, dry powder inhalers and methods

Pharmaceutical dry powder containers adapted for use in an inhaler and associated inhalers and kits thereof include at least a pair of cooperating generally tubular members, including an inner member and a generally tubular outer member sized and configured to slidably receive the inner member. In operation, at least one of the inner or outer members slide relative to the other to release a pharmaceutical dry powder.

Tubular dry powder drug containment systems, associated inhalers and methods

Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods

Growing community of inventors

Durham, NC, United States of America

Michael L King