Mayo Foundation for Medical Education and Research

The University of British Columbia

The University of Manchester

Vib Vzw

Universiteit Antwerpen

Michael L Hutton

Jason Eriksen

Stuart M Pickering-Brown

Christine Van Broeckhoven

Matthew Charles Baker

Jennifer Mae Gass

Rosa Rademakers

Ian Reid Alexander Mackenzie

Howard Feldman

Samir Kumar-Singh

Marc Cruts

Ashley Diane Cannon

Eileen M McGowan

Jada M Lewis

This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Detecting and treating dementia

Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau pathology also are described.

Pathogenic Tau mutations in transgenic mice

Growing community of inventors

Newton, MA, United States of America

Michael L Hutton