Neurosolis, Inc.

Michael L Hendrickson

Richard R Copp

Seth A Hanson

Jeffrey C Ockuly

Brent D Abraham

Trevor M Twose

James G Farnham

Melinda L Verdone

The invention relates generally to muscarinic agonists, which are useful for stimulating muscarine receptors, and treating cognitive disorders. Included among the muscarinic agonists disclosed herein are oxadiazole derivatives, compositions, and preparations thereof. Methods of synthesizing oxadiazole compounds also are provided. This disclosure also relates in part to compositions for enhancing cognitive function in subjects such as humans, the compositions comprising a muscarinic agonist or a pharmaceutically suitable form thereof. This disclosure relates in part to methods of treating animals such as humans by administering such compositions.

Cognition enhancing compounds and compositions, methods of making, and methods of treating

Disclosed are muscarinic agonist compounds including oxadiazole derivatives, compositions and preparations thereof. Also disclosed are methods of synthesizing such oxadiazole compounds. Further disclosed are methods for treating a subject with said muscarinic agonists or a pharmaceutically suitable form thereof to enhance cognitive function.

Compounds and compositions for cognition-enhancement, methods of making, and methods of treating

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Madison, WI, United States of America

Michael L Hendrickson