University of Minnesota

Michael Kyba

Darko Bosnakovski

Daniel F Voytas

Rita Perlingeiro

Fabrizio Rinaldi

Sun Kin Sunny Chan

Ning Xie

Natalya Goloviznina

Robert W Arpke

Abhijit Dandapat

A method for treating a cancer involving one or more translocations generating an oncogenic fusion transcription factor that requires p300/CBP for activity in an animal, comprising administering a compound of formula (I):

Methods for treating cancer

The present disclosure provides methods of producing a preparation of fibroadipogenic progenitors (FAPs) from a cell mixture. In certain embodiments, the present disclosure provides a method of producing a preparation of human FAPs from a skeletal muscle biopsy sample for later use.

Methods for producing fibroadipogenic progenitor cells

A method for treating a cancer involving one or more translocations generating an oncogenic fusion transcription factor that requires p300/CBP for activity in an animal, comprising administering a compound of formula (I): or a pharmaceutically acceptable salt thereof to the animal.

Compositions and methods of the invention are directed to the formation and use of teratoma-derived skeletal muscle stem cells. In one embodiment, the teratoma-derived skeletal muscle stem cells improve muscle contractile force (definition 'functional') when administered to a patient in need thereof.

Method of generating skeletal muscle stem cells from pluripotent cells

Provided herein is a general method of correcting a gene, for example a gene with many known mutations, such as a gene with mutations in many different exons which could vary from subject to subject (e.g., patient), as well as a set of tools (TALENs and gene targeting vectors) to accomplish such method.

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Saint Paul, MN, United States of America

Michael Kyba