Nanostring Technologies, Inc.

Epigenomics Ag

Michael Krouse

Joseph M Beechem

Dwayne L Dunaway

Isaac Sprague

Rustem Khafizov

Lucas M Dennis

Qian Mei

Reimo Tetzner

Fabian Model

Juergen Distler

Matthias Schuster

Andrew Z Sledziewski

Jürgen Distler

Theo Devos

Cathy E Lofton-Day

Jesse Ho

Lucas Dennis

Cathy Lofton-Day

Mathias Schuster

The present disclosure is directed to systems, devices and methods for nucleic acid or protein purification and imaging. A system is provided including a cartridge comprising a sample input area configured to hold a sample, comprising a plurality of hybridized complexes comprising a plurality of target molecules each hybridized with probes and a plurality of non-hybridized probes. The cartridge may also include a first binding chamber configured with first magnetic beads to receive and bind the sample, a first elution channel configured to receive the first magnetic beads and elute the sample from the first magnetic beads, a second binding chamber configured with second magnetic beads to receive and bind the sample, a second elution channel configured to receive the second magnetic beads and elute the sample from the second magnetic beads, and a binding area configured to receive the eluted sample and hold molecules for imaging.

Methods and apparatuses for gene purification and imaging

Aspects of the invention relate to composition and methods for the providing of DNA for methylation analysis that is in particular suitable to be applied in reference laboratories. Further 5 aspects of the invention relate to composition and methods for the highly specific and sensitive methylation analysis of the Septin 9 gene also in particular suitable to be applied in reference laboratories.

Method for methylation analysis

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Seattle, WA, United States of America

Michael Krouse