Astrazeneca Ab

Albireo Ab

Michael Kossenjans

Karl Henrik Edman

Eva-Lotte Lindstedt-Alstermark

Maria Boije

Andrew Turner

Johan Gottfries

Bengt Ohlsson

Anders Broo

Philip Cornwall

Johan Kajanus

Li Lanna

Kristina A Nilsson

Maria Thorstensson

Gavin O'Mahony

Carl Anders Hogner

Karl Anders Hogner

Karl Edman

Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, (Formula (I)) that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds. 

Benzoxazinone amides as mineralocorticoid receptor modulators

Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl)propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl)propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methyl or ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.

2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease

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Molndal, Sweden

Michael Kossenjans