University of Iowa Research Foundation

Ethris Gmbh

Eberhard Karls Universitat Tubingen Medizinische F Akultat

Helmholtz-Zentrum FÜr Infektionsforschung Gmbh FÜr Das Helmholtz-Institut FÜr Pharmazeutische Forschung Saarland (Hips)

Michael Kormann

Carsten Rudolph

Aliasger Karimjee Salem

Liu Hong

Brigitta Loretz

Claus-Michael Lehr

Satheesh Elangovan

Sheetal Reginald R D'mello

Anh-Vu T Do

Lauren Mays Weddle

Emad Malaeksefat

Behnoush Khorsand-Sourkohi

Alexander Dewerth

Ashiqul Haque

Justin S Antony

Lauren Mays

The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.

Permanent gene correction by means of nucleotide-modified messenger RNA

The invention relates to a polyribonucleotide with a sequence that codes a protein or protein fragment, wherein the polyribonucleotide comprises a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidin nucleotides are modified uridine nucleotides or modified cytidin nucleotides.

RNA with a combination of unmodified and modified nucleotides for protein expression

The present disclosure provides compositions and methods useful for tissue engineering including a composition having chemically modified RNA (cmRNA) encapsulated in or complexed with a non-viral delivery vehicle and a biocompatible, bioresorbable scaffold and methods of using the composition to regenerate, for example, bone tissue.

RNA based biomaterial for tissue engineering applications

Growing community of inventors

Tübingen, Germany

Michael Kormann