Abbott Gmbh & Co Kg

Basf Aktiengesellschaft

Basf Plant Science Gmbh

Abbott Laboratories Corporation

Abb Vie Deutschland Gmbh & Co. Kg

Abbvie Deutschland Gmbh and Co Kg

Michael Kock

Wilfried Lubisch

Jörg Bauer

Roland Grandel

Sabine Schult

Thomas Höger

Reinhold Mueller

Thomas Hoeger

Burkhard Kröger

Linda Patricia Loyall

Hee-Sook Song

John McMillan

Jeffrey A Brown

Hans-Georg Lemaire

Hongmei Jia

Liqun Xing

Thomas H&ouml;ger

Lesley Ireland

Uta Holzenkamp

Bernd Otterbach

Markus Frank

Thomas Hoger

Ralf Badur

Jens Sadowski

Reinhold Müller

Reinhold M&uuml;ller

Wilfried Lubish

Joerg Bauer

John Mcmillan

The invention relates to efficient, high-throughput methods, systems, and DNA constructs for identification and isolation of transcription termination sequences. The invention relates further to specific terminator sequences identified by said methods isolated from rice.

Method for isolation of transcription termination sequences

The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has

Poly(ADP-ribose) polymerase genes

The invention relates to efficient, high-throughput methods, systems, and DNA constructs for identification and isolation of transcription termination sequences. The invention relates further to specific terminator sequences identified by the methods isolated from rice.

The present invention relates to processes for preparing transformed plant cells or organisms by transforming a population of plant cells which comprises at least one marker protein having a direct or indirect toxic effect for said population, with at least one nucleic acid sequence to be inserted in combination with at least one compound, preferably a DNA construct, capable of reducing the expression, amount, activity and/or function of the marker protein, with the transformed plant cells having a growth advantage over nontransformed cells, due to the action of said compound.

Selection method

The invention relates to novel 2-phenylbenzimidazoles of general formula (I) or (II), wherein the radicals have the meanings cited in the description, and to their tautomeric forms, possible enantiomeric and diastereomeric forms, to their prodrugs, and to possible physiologically compatible salts. The invention also relates to the production of said compounds and to their use.

Substituted 2-phenylbenzimidazoles, the production thereof and their use

Poly(ADP-ribose) polymerase-gene

Substituted benzimidazoles and their use as PARP inhibitors

The present invention relates to novel indole derivatives, to their preparation and to their use, as inhibitors of the enzyme poly(ADP-ribose)polymerase or PARP (EC 2.4.2.30), for producing drugs.

Substituted indoles which are PARP inhibitors

The invention relates to compounds of the formula Iand the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.

Heterocyclic compounds and their use as PARP inhibitors

The present invention relates to the use of phthalazine derivatives as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30), to the use as inhibitors of PARP-homologous enzymes and, in particular, these phthalazine derivatives also show a selective inhibition of PARP-homologous enzymes.

Use of phthalazine derivatives

Cyclo-alkyl substituted benzimidazoles and their use as PARP inhibitors

The present invention relates to novel benzimidazoles, their preparation and their use as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30) for producing drugs.

Heterocyclically substituted benzimidazoles, the production and application thereof

2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof

Substituted benzimidazoles and their use as parp inhibitors

Growing community of inventors

Schifferstadt, Germany

Michael Kock