Empire Technology Development LLC

Xinova, LLC

Michael Keoni Manion

George Charles Peppou

Benjamin William Millar

Vincenzo Casasanta, Iii

Takahisa Kusuura

Timothy Martin Londergan

Feng Wan

Christopher J Rothfuss

Deniz Ozdil

Christopher John Buntel

Stephanie Brunelle

Benjamin Matthew Austin

Benjamin Watson Barens

Technologies are described for delivery of compounds to aid in weight management. A transdermal microdispenser based system may deliver weight management compounds through the time and dose specific administration of appetite suppression, metabolic enhancers, and satiation compounds. The transdermal delivery system may be controlled based on data associated with subject such as calorie intake, physical activity, satiation, and hunger. The system may be integrated with medical monitoring or fitness tracking systems. Delivery of the compounds may be distributed over the course of a day at selected or adjusted doses to be safe and effective for their specific modality. For example, appetite suppressants may be delivered during periods of the day when cravings occur, satiation compounds may be delivered to coincide with meals, and metabolic stimulators may be delivered at times to optimally increase metabolism based on caloric balance. Control factors may also be predictive to prevent the onset of hunger.

Smart transdermal microdispensing system for integrated weight management

Liposomal detection devices and methods of making and using such devices are disclosed. Such liposomal detection devices may be used to detect microbes by detecting a byproduct of microbial metabolism, or may be used to detect changes in pH and/or changes in temperature. Liposomal detection devices may include a first liposome encapsulating a first destabilizing compound and a second liposome encapsulating a second destabilizing compound. The first liposome may destabilize in response to the detection of the target compound or change to release the first destabilizing compound which may destabilize the second liposome. A matrix, such as a hydrogel matrix, may encase the first liposome and the second liposome.

Liposomal detection devices and methods for their use and preparation

Technologies are generally described to monitor a sweat rate of an area of a skin. A hydration status of a human or non-human entity is monitored based on the sweat rate. The sweat rate is monitored when the sweat rate monitor is detected as sealed against the surface of the skin. The sweat rate monitor is attached to the surface of the skin with an adhesive, or a tape among other schemes to hold the sweat rate monitor in place during a measurement. The sweat rate monitor includes a container to capture an initial amount of sweat that comes out of the surface of the skin. When, the container is detected as filled with the initial amount of sweat, a pump of the sweat rate monitor is actuated to compress the container. The container is compressed to force a volume of the initial amount of sweat in the container out of an ejection port of the sweat rate monitor.

Single-chambered sweat rate monitoring sensor

Compositions and methods for changing a property of a coating are provided. The coating includes a dynamic material configured to be reversibly convertible between a hydrophobic state and a hydrophilic state, wherein transition between the hydrophilic state to the hydrophobic state occurs in an environment dependent manner. The coating also includes an environment altering material configured to alter the hydrophobic or hydrophilic state of the dynamic material.

Dynamic surfaces

Embodiments described herein provide for terahertz tags and methods of making and using them. A tag may include a terahertz reflective material; and a saturated hygroscopic material positioned on the terahertz reflective material. A tag may include a terahertz reflective material; and an anhydrous hygroscopic material positioned on the terahertz reflective material. A humidity sensor may include a terahertz reflective material; and an anhydrous hygroscopic material positioned on the terahertz reflective material. A temperature sensor may include a terahertz reflective material; an anhydrous hygroscopic material positioned on the terahertz reflective material; and a polymer overlay having thermally controlled water permeability disposed on the anhydrous hygroscopic material. Some embodiments relate to a tag identification device configured to transmit an incident signal toward the tag, and to receive a reply signal from the tag in response to the incident signal.

Terahertz frequency tags and methods for their preparation and use

A matrix material dispersed with one or more susceptor structures can be formed into a feedstock for an additive manufacturing process. The one or more susceptor structures can be excited by an energy field such as an electric field, a magnetic field, an electromagnetic field, or any combination thereof, to produce heat. The heat that is produced can be transferred to the matrix material that surrounds the one or more susceptor structures to provide heat treatment to the matrix material. The heat treatment can improve the material and mechanical properties of three dimensional objects formed from the feedstock.

Spatial heat treatment of additively manufactured objects

An apparatus is disclosed that may include a substrate that may have a surface, a channel of a volume that may be defined, at least in part, by the substrate, wherein the channel may have a first end and a second end, a valve may be coupled to the channel at the first end, wherein the valve may be configured to allow a fluid to pass into the channel when the valve is open, and a continuity detector, which may be coupled to the channel at the second end, wherein the continuity detector may be activated when the fluid contacts the continuity detector, wherein the continuity detector may further be configured to provide a signal to close the valve and remove the fluid from the channel. A method for calculating a rate of flow of a fluid collected from a bodily surface into a body-worn device is disclosed.

Portable flow meter for low volume applications

Technologies are generally described for devices for detection of a biofilm by a color change in a moisture-indicating substance, such as a chemical or a dye. The moisture indicating material may be supported by a substrate and sealed to keep moisture from the moisture indicating material. Alternatively, the moisture indicating material may be supported in a pouch and sealed by the pouch. The color change results from an ingress of moisture accompanying growth of a biofilm. The moisture-indicating substance may be used with indwelling or other devices to detect a biofilm. When the biofilm has sufficiently degraded the seal, an ingress of moisture and its accompanying pH may cause a color change in the moisture-indicating substance to signify the presence of the biofilm. Methods of manufacture and use of the disclosed devices are also described.

Color change indicator of biofilm formation

Some embodiments provided herein relate to bioluminescent packaging, methods of making, and methods of sensing the state of a material. In some embodiments, light emitted by a bioluminescent organism can be used to sense the state of a material.

Bioluminescent packaging

Embodiments provided here generally relate to combinations of ultrasound aspects and antibodies. In some embodiments, antibodies are immobilized on a surface and binding of the antibodies to antigens can be detected by detecting changes in the vibrational properties of the surface.

Ultrasound based antigen binding detection

Symbologies for encoding data, as well as methods of encoding and decoding thereof are described. The symbologies may have a plurality of pixels arranged in a plurality of patterns on or in a substrate. Furthermore, each of the plurality of pixels may have one or more optical properties that each provides one or more types of non-interacting data.

Orthogonal encoding for tags

Antibodies and antibody fragments that selectively bind to nanoparticles are provided herein.

Chicken antibodies that bind to nanoparticles

Technologies are disclosed for a method and a device for detecting device colonization. Disclosed herein is an indwelling medical device configured to detect a biofilm. The device comprises a substrate configured to contact blood and a detecting material, disposed with the substrate, configured to detect the presence of a biofilm thereon. The detecting material is soluble in blood, removable by kidneys from the blood, and passable to urine by the kidneys for detection in the urine. A method for detecting the growth of a biofilm on an indwelling medical and a method for making an indwelling medical device are also disclosed herein.

Method and device for detecting device colonization

Provided herein are methods and devices for sensing air quality. In some embodiments, materials from mitochondrial membranes, and/or material that is present in mitochondrial membranes can be used as a detection system to optically detect the presence and/or absence of various materials.

Growing community of inventors

Cronulla, Australia

Michael Keoni Manion