Ge Healthcare UK Limited

Amersham International Plc

Ge Healthcare Limited

Michael Kenneth Kenrick

Erik Leeming Kvam

Nicholas Thomas

Margaret P Raybuck

David A Parry

John George Anson

Cheryl Louise Potts

Wei Gao

Geraint Seymour

Kathryn Louise Lamerton

Simon L Stubbs

Arne Lundin

Bonnie Lee Webster

Nicola M Williamson

Andrew L Bertera

Fiona Elizabeth Allan

Aidan Mark Emery

Sharon Joanne Murathodzic

The present invention relates to the field of nucleic acid collection and storage, and in particular to the collection and long-term storage of nuclei. The invention provides a device and method which can be used to capture and store nuclei at ambient temperatures allowing the subsequent isolation of nucleic acids by passive washing with a wash buffer. The present invention also provides a kit including the device of the invention suitable for carrying out the method of the invention.

Device and method for cell nuclei preparation

A method of performing data management in a high-speed data environment. The method includes collecting time-series information including multiple data types captured concurrently, and storing the collected time-series information in a process historian with organization, the organization occurring when the multiple data types are captured.

Method for nuclei storage

The present invention relates to methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. For easy processing and amplification of nucleic acid samples, the samples are bound to a solid support and used directly, without purification, in a nucleic acid amplification reaction such as the polymerase chain reaction (PCR).

Methods for one step nucleic acid amplification of non-eluted samples

The present invention to relates to methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. The PCR reagents are bound to a solid matrix for easy processing and amplification of DNA samples.

Solid matrix for one step nucleic acid amplification

A device for capturing a component present in a fluid is a pipette tip having a rearward end 15 adapted to be fitted on a micro-pipette, and a forward end 12 with a membrane 17, adapted to bind the component, extending across the pipette tip.

Device and method for affinity separation

A method of preparing nucleic acids by obtaining an impure nucleic acid preparation, treating said preparation with phenol and adding a cyclodextrin to the treated preparation to neutralize the phenol.

Methods and kits for preparing nucleic acids using cyclodextrin

A device for capturing a component present in a fluid 18 a pipette tip having a rearward end 15 adapted to be fitted on a micro-pipette, and a forward end 12 with a membrane 17, adapted to bind the component, extending across the pipette tip.

A method of separating cell nuclei from cells comprises: treating a fluid containing whole cells so as to selectively lyse the cytoplasmic membrane together with a small proportion of the nuclear membranes but leaving a large proportion of the cell nuclei intact; applying the treated fluid to a membrane whereby a mesh of DNA from the lysed nuclei is formed on the surface and captures intact cell nuclei. A device for use in the method is described.

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Cardiff, United Kingdom

Michael Kenneth Kenrick