Arizona State University

Michael Keebaugh

Mark A Hayes

Thomas J Taylor

Paul Jones

Prasun Mahanti

Sarah Staton

Stacy Kenyon

Noah Weiss

The present invention provides devices and methods to separate and concentrate target species. In some embodiments, a punctuated continuous microchannel or parallel processing (array-based) separations are provided, the microchannel having a plurality of sequential, constrictive insulating features to form a plurality of reservoirs including a first, second and third reservoir, and a plurality of constricted passageways including a first constricted passageway that connects the first reservoir to the second reservoir and a second constricted passageway that connects the second reservoir to the third reservoir. A voltage is applied to the microchannel to create different electrical fields and/or different dielectrophoresis (DEP) gradients at each of the plurality of constricted passageways in order to separate species that have differing ratios of electrokinetic mobility to dielectrophoretic mobility.

Punctuated microgradients for improved separations of molecules and particles

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Mesa, AZ, United States of America

Michael Keebaugh