Hercules Corporation

Aventis Pharmaceuticals Inc.

Aventis Pharmaceuticals Products Inc.

Rhone-poulenc Rorer Pharmaceuticals Inc.

Herecules Incorporated

Michael K O'Brien

Paul J Shannon

Robert P Grasso

Wayne M Gibbons

Shao-Tang Sun

Patrick Leon

Matthew R Powers

Luc Grondard

Tory H Powner

Adam W Sledeski

Ching T Tsuei

Daniel Robin

Jean-Paul Casimir

Benoit J Vanasse

James P Sherbine

Walter Rodriguez

Rick G Woodward

Herve Garcia

Gregory G Kubiak

Laurence W Reilly

Diane C Salazar

Laurence Pailleres-Hubert

Benoit Viguier

Francis L Walther

Michael D Thompson

Harshavadan C Shah

Sithamalli V Chandramouli

Methods for stereoselective substitution in which a (mono or un)-&agr;-substituted unprotected &bgr;-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hydride, lithium amide, lithium dialkyl amides and alkali hexamethyldisilylamines.

Alpha-substitution of unprotected &bgr;-amino ester compounds

This invention is directed to methods for stereospecifically preparing &lsqb;(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)&rsqb;-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.

Steroespecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines

This invention is directed to a process for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.

Process for preparing N6-substituted adenosine derivatives

The invention is directed to improved methods for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.

This invention is directed to methods for the preparation of [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chloro-2-thienyl) methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxyc yclopentanecarboxamide, methods for the preparation of intermediates thereto, and to said intermediates themselves.

Preparation of

This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.

Stereospecific preparation of chiral 1-aryl-and

Organosilicon polymers, including crosslinked polymers and crosslinkable prepolymers, of cyclic polysiloxanes, organic dyes, and, optionally, polyenes. The dyes include those with delocalized Pi electron systems linking electron donor groups and electron acceptor groups, and with at least two carbon--carbon double bond-containing pendant groups attached to at least two different sites from among the indicated delocalized Pi electron systems, donor groups, and acceptor groups.

Nonlinear optical media of organosilicon crosslinked polymer

Organosilicon polymers, including crosslinked polymers and crosslinkable prepolymers, of cyclic polysiloxane, organic dyes, and, optionally, polyenes. The dyes include those with delocalized Pi electron systems linking electron donor groups and electron acceptor groups, and with at least two carbon-carbon double bond-containing pendant groups attached to at least two different sites from among the indicated delocalized Pi electron systems, donor groups, and acceptor groups.

Organosilicon polymers, and dyes, exhibiting nonlinear optical response

Organosilicon polymers, including crosslinked polymers and crosslinkable prepolymers, of cyclic polysiloxanes, organic dyes, and, optionally, polyenes. The dyes include those with delocalized Pi electron systems linking electron donor groups and electron acceptor groups, and with at least two carbon-carbon double bond-containing pendant groups attached to at least two different sites from among the indicated delocalized Pi electron systems, donor groups, and acceptor groups. Also disclosed are optical substrates coated with the organosilicon crosslinked polymers exhibiting second order non-linear optical susceptibility.

Arylazo and poly(arylazo) dyes having at least one core radical selected from naphthyl or anthracyl and having at least one 2,3-dihydro-1,3-dialkyl perimidine substituent, a guest-host composition comprising a liquid crystal host solvent and the arylazo or poly(arylazo) dichroic dye, and a liquid crystal display comprising the guest-host composition, are disclosed.

Dichroic azo dyes

Arylazo and poly(arylazo) dyes having at least one core radical selected

Organosilicon polymers, including crosslinked polymers and crosslinkable prepolymers, of cyclic polysiloxanes, organic dyes, and, optionally, polyenes. The dyes include those with delocalized Pi electron systems linking electron donor groups and electron acceptor groups, and with at least two carbon-carbon double bond-containing pendant groups attached to at least two different sites from among the indicated delocalized Pi electron systems, donor groups, and acceptor groups.

Growing community of inventors

Berwyn, PA, United States of America

Michael K O'Brien