Sloan-Kettering Institute

Immunom Technologies, Inc.

Michael K Hoffmann

William E Marshall

Methods and compositions for modulating the immune system of animals by activating macrophages to release cytokines and down-regulating their sensitivity to bacterial endotoxin and to conversion to cytotoxic phenotypes by the administration of stress response factors released by stressed bacteria. Methods and compositions for protecting the viability of liquid or dried cultures of bacteria by the administration of stress response factors released by stressed bacteria.

Methods and compositions for modulating immune systems of animals

Antibody producing human B-lymphocytes are produced by a process which comprises culturing human B-lymphocytes in a tissue culture medium in the presence of an antigen; helper signal producing agents comprising monocytes or monocyte conditioned medium containing Interleukin 1 (I1-1), and helper T-lymphocytes or helper T-lymphocyte replacing factor; and human serum; and thereafter recovering the antibody producing cells from the medium.

Growing community of inventors

New York, NY, United States of America

Michael K Hoffmann