Gilead Pharmasset LLC

Gilead Sciences, Inc.

Pharmasset, Inc.

Gilead Pharmassel LLC

Michael Joseph Sofia

Jinfa Du

Peiyuan Wang

Dhanapalan Nagarathnam

Ganapati Reddy Pamulapati

Bruce Ross

Hai-Ren Zhang

Suguna Rachakonda

Byoung-Kwon Chun

Wonsuk Chang

Dhanpalan Nagarathnam

Phillip Furman

Devan Naduthambi

Donghui Bao

Bruce S Ross

Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

Nucleoside phosphoramidate prodrugs

Embodiments of the invention are to compounds, methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention are 2',4&#x2032;-substituted nucleoside compounds useful for the treatment of viral infections, such as HIV, HCV, and HBV infections.

2',4&#x2032;-substituted nucleosides as antiviral agents

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.

Nucleoside phosphoramidates

Disclosed herein are 2'-spiro-nucleosides and derivatives thereof useful for treating a subject infected by hepatitis C virus or dengue virus.

2'-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.

A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.

Synthesis of purine nucleosides

A nucleoside compound having activity against hepatitis C virus is disclosed.

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Doylestown, PA, United States of America

Michael Joseph Sofia