Pfizer Corporation

Michael Joseph Melnick

Matthew Frank Brown

Usa Reilly

Justin Ian Montgomery

Ye Che

Anthony Marfat

Jinshan Michael Chen

Mark Stephen Plummer

Loren Michael Price

Richard Andrew Ewin

Timothy Allan Johnson

Tamim F Braish

Daniel Paul Uccello

Joseph Alan Abramite

Mathew Frank Brown

Joseph A Abramite

The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH), —P(O)(OH)(OM), —P(O)(OM)and —P(O)(O)M; Mat each occurrence is a pharmaceutically acceptable monovalent cation; and Mis a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Fluoro-pyridinone phosphates and boronates useful as antibacterial agents

The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, wherein the variables G, T, D, L, A, X, Rand Rare as described hereinabove, and their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.

C-linked hydroxamic acid derivatives useful as antibacterial agents

The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.

N-link hydroxamic acid derivatives useful as antibacterial agents

The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents

Fluoro-pyridinone derivatives useful as antibacterial agents

Isoxazole derivatives useful as antibacterial agents

The present invention is directed to a new class of hydroxamic acid derivatives of formula I, 

N-linked hydroxamic acid derivatives useful as antibacterial agents

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Portage, MI, United States of America

Michael Joseph Melnick