American Cyanamid Company

Michael Joseph Daley

Susan Mancini Cady

Brian Lee Buckwalter

Peter Bohlen

Andrew P Seddon

Hong-Ming Shieh

Phillip Wayne Hayes

Gary J Furda

William David Steber

Elizabeth R Oldham

Paul A Johnston

The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.

Stabilization of fibroblast growth factors by modification of cysteine

The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing the derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.

Stabilization of somatotropins and other proteins by modification of

A method of reversing or preventing immunosuppression or antigenic interference associated with combination vaccines in mammals, is disclosed. Cytokines, or cytokine inducer, are administered in conjunction with the combination vaccine. The cytokine or cytokine inducer can be administered concurrently with or subsequently to the vaccine, and can be recombinantly produced or isolated from cell culture.

Method of reversing immunosuppression in vaccines

A therapeutic composition which contains a potentiating or safening amount of an aqueous surfactant in combination with a bactericidal agent and/or a biological response modifier is described herein. The disclosure further describes an improved method for treating mastitis by administering the composition to an afflicted mammal. Additionally, the disclosure describes a method for screening suitable formulations for treating infectious diseases.

Compositions for the treatment of mammalian diseases

Cytokines are useful for the ability to improve the natural defense system of the involuting mammary gland. In addition to the immunopotentiating activity, cytokines accelerate the normal physiology of involution of the mammary gland and thereby afford further protection against new infections of mammals. The involuting mammary gland is very susceptible to infection during the early stages of involution and therefore decreasing the period of highest susceptibility while also improving the natural defense mechanisms is of great advantage over most therapies. Used alone, in various cytokine combinations, or in combination with other therapeutics, cytokines protect the mammary gland and cure existing infections and are particularly useful during cessation of lactation and early reinitiating of lactation.

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Yardley, PA, United States of America

Michael Joseph Daley