James Black Foundation Limited

Michael John Pether

Sarkis Barret Kalindjian

Iain Mair McDonald

Matthew John Tozer

Caroline M Low

Ildiko Maria Buck

David John Dunstone

Katherine Isobel Steel

Jonathan Michael Davies

Nigel Paul Shankley

Elaine Anne Harper

Ian Duncan Linney

Martin Lyn Hudson

Paul Wright

Caroline Minli Rachel Low

Katherine Isobel Mary Steel

Gillian Fairfull Watt

Tracey Cooke

James Black

Robert A Hull

Sonia Patricia Roberts

Martin Keith Walker

Elliot James Lilley

David Andrew Sykes

Eric Peter Griffin

Laurence Wright

Katherine Isabel Mary Steel

John David Gaffen

Robert Antony David Hull

Michael J Bodkin

Jeremy Gilbert Vinter

Ligands for the gastrin and cholecystokinin (CCK) receptors are provided, together with methods for preparing such ligands, and compounds which are useful intermediates in such methods. Pharmaceutical compositions comprising such ligands, methods for preparing such pharmaceutical compositions, and methods of treatment using these compositions also are provided. The ligands have the formula (I):where n is from 1 to 3;

Gastrin and cholecystokinin receptor ligands(II)

Gastrin and cholecystokinin receptor ligands

1H-4(5)-substituted imidazole derivatives, their preparation and their use as histamine H3 receptor ligands

Sulfonamides and sulfamides as H.sub.3 receptor antagonists

Benzodiazonine derivatives binding to cholecystokinin or gastrin

Compounds of formula (Ia), (Ib), or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R.sup.1.sub.(m) represents up to 6 substituents, K represents --O--, --S--, --CH.sub.2 --, --N(R.sup.2)-- or --N(COR.sup.2)--, in which R.sup.2 is H or C.sub.1 to C.sub.3 alkyl, W is a carbonyl, sulfonyl or sulfinyl group, provided that at least one of W and X contains carbonyl, Y and Z are as given in the description, and their pharmaceutically acceptable salts are ligands at CCK and/or gastrin receptors. ##STR1##

Gastrin and cck receptor ligands

Gastin and CCK receptor ligands

Bicyclooctane and bicycloheptane derivatives

The compounds of the formula I ##STR1## and their pharmaceutical acceptable salts, which are defined herein, are ligands for cholecystokinin and/or gastrin receptors.

Bicyclo 2,2,2!octane derivatives

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London, United Kingdom

Michael John Pether