Eli Lilly and Company

Michael John Mayer

Michael Robert Wiley

Christopher William Murray

John Joseph Masters

Peter Guzzo

Brian Morgan Watson

John Walter Liebeschuetz

Stephen Clinton Young

Stuart Donald Jones

Nicholas Paul Camp

Scott Martin Sheehan

William Alexander Wylie

David Birenbaum Engel

Compounds of formula (I) in which R, X, Y, Cy, L and Lp(D)have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.

Serine protease inhibitors

The compound 1-(indole-6-carbonyl-D-phenylglycinyl)-4-(1-methylpiperidin-4-yl)piperazine and physiologically-tolerable salts thereof are factor Xa inhibitors useful for the treatment of thrombotic disorders.

Compounds of formula (I)in which R, X, Y, Cy, L and Lp(D)have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.

Growing community of inventors

Gulderland, NY, United States of America

Michael John Mayer