Pharmacia & Upjohn Company

Other

Pfizer Corporation

Agouron Pharmaceuticals, Inc.

Sugen Incorporated

Zoetis LLC

Michael John Hawley

Peng Cho Tang

Walter Morozowich

Congxin Liang

Chung Chen Wei

Todd Anthony Miller

Asaad S Nematalla

Tomas Vojkovsky

Xiaoyuan Li

Mark Peter Warchol

Shahrzad Shirazian

Li Hsiang Sun

Malcolm Wilson Moon

Patrick J Lennon

Dominique Bonafoux

Ivan Richards

Sergey Gregory Wolfson

Sue K Cammarata

Craig D Wegner

Mark Kontny

Karen Patrice Kolbasa

Mark Maloney

Todd P Foster

Connie Li Sun

Thomas J Fleck

Satish Kumar Singh

Changquan Sun

Wladyslaw Hanower

Fusen Han

Changquan C Sun

Pam Hanower, Legal Representative

Tom Thamann

Pete Merrill-Oldham

Paul A Parisi

Stephen P Prescott

An apparatus for shaping a Platelet Rich Fibrin component of patient whole blood includes a main body. The main body includes a substantially planar surface. The main body also has a reservoir positioned therein. The substantially planar surface includes a plurality of channels fluidly connecting the substantially planar surface and the reservoir. The apparatus also includes a lid which is positioned over the substantially planar surface. The lid is used to compress a Platelet Rich Fibrin component. Liquids that are expressed from the Platelet Rich Fibrin component flow to the reservoir. The apparatus also includes openings for forming plugs of Platelet Rich Fibrin material.

Apparatus and method for producing augmentive products

The present invention relates to solid salt forms of the 3-pyrrole substituted 2-indolinone compound 5-[5-fluoro-2-oxo-1, 2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pirrolidin-1-yl-ethyl)-amide. It also relates to polymorphs of the phosphate salt of the amide. The invention further relates to the use of the salts and polymorphs in the treatment of protein kinase related disorders.

Solid salt forms of a pyrrole substituted 2-indolinone

In a method for producing large-scale pages of a book, one or a plurality of long sheets of paper or other flexible material is folded in an alternative forward and reverse direction along a single axis, yielding an accordion fold structure. Such pages are bound along a single edge to yield a book of enormous proportion. According to one exemplary embodiment, each page of the book is of approximately five feet by seven feet in dimension, yielding a compelling visual display that may contain life-sized portraits, brilliant landscapes, detailed maps, a panoply of disparate visual images, text, diagrams, or blank pages for creative uses. Methods of binding may include tabbing folds of the pages and then stitching through the tabs.

Methods and systems for providing large-scale books

The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Pyrrole substituted 2-indolinone protein kinase inhibitors

The present invention relates to polymorphs of the 3-pyrrole substituted 2-indolinone compound 5-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide.

Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors

The compound 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(trifluoromethyl) phenol may be used to prepare the compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide by reaction with methyl bromide.

Phenol derivative

The present invention provides crystals, and compositions thereof, wherein the crystals include a malic acid salt of N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide. Methods of preparing such crystals are also disclosed.

Crystals including a malic acid salt of a 3-pyrrole substituted 2-indolinone, and compositions thereof

The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

The present invention concerns novel pharmaceutically active compounds, pharmaceutical compositions containing the same, the compounds for use as medicaments, and use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are pharmaceutically acceptable salts of tolterodine or hydroxytolterodine, wherein the salt is of an acid selected from the group consisting of aliphatic mono- and dicarboxylic acids comprising from 7 to 24 carbon atoms, alkanedisulfonic acids comprising from 2 to 4 carbon atoms, naphthoic acid derivatives comprising from 11 to 27 carbon atoms, maleic acid and fumaric acid.

Tolterodine salts

Novel quaternary ammonium compounds of the formulaand any stereoisomers thereof, wherein R, Rand Rindependently represent C-Calkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R, Rand Rmay form a ring together with the quaternary ammonium nitrogen; Rrepresents &#x2014;H, &#x2014;CH, or &#x2014;CO&#x2014;R, wherein Rrepresents &#x2014;(C-Calkyl), &#x2014;(C-Calkoxy), or &#x2014;NRR, wherein Rand Rindependently represent &#x2014;H or &#x2014;(C-Calkyl); R, Rand Rindependently represent &#x2014;H, &#x2014;OCH, &#x2014;OH, &#x2014;CONH, &#x2014;SONH, &#x2014;F, &#x2014;Cl, &#x2014;Br, &#x2014;I, &#x2014;CF, or &#x2014;(C-Calkyl), optionally substituted with one or two &#x2014;OH, &#x2014;(C-Calkoxy), &#x2014;COOH, or &#x2014;CO&#x2014;O&#x2014;(C-Calkyl); and Xrepresents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.

Quaternary ammonium compounds

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Clear Lake, SD, United States of America

Michael John Hawley