British Biotech Pharmaceuticals Limited

British Bio-technology Limited

Michael John Crimmin

Jonathan P Dickens

Alan H Davidson

Raymond Paul Beckett

Colin Campion

Andrew Paul Ayscough

William Alan Galloway

Andrew John Gearing

Mark Hampton Davis

Andrew J Gearing

William A Galloway

Compounds of general Formula I: ##STR1## are presented which have collagenase inhibition activity and are useful in the management of disease involving tissue degradation and the promotion of wound healing. Representative diseases involving include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption disease and tumor invasion.

Compounds

Hydroxamic acid derivatives as inhibitors of cytokine production

Hydroxamic acid derivatives as metalloproteinase inhibitors

Hydroxamic acid derivatives

Inhibition of TNF production with matrix metaloproteinase inhibitors

Natural amino acid derivatives as metalloproteinase inhibitors

Compounds of general formula I: ##STR1## wherein: R.sup.1 represents a C.sub.1 -C.sub.6 alkyl, phenyl, thiophenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.6)alkyl, heterocyclyl, (C.sub.1 -C.sub.6)alkylcarbonyl phenacyl or substituted phenacyl group; or, when n=O, R.sup.1 represents SR.sup.x, wherein R.sup.x represents a group: ##STR2## R.sup.2 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl(C.sub.1 -C.sub.6)alkyl, cycloalkyl(C.sub.1 -C.sub.6)alkyl or cycloalkenyl(C.sub.1 -C.sub.6)alkyl group;

Hydroxamic acid based collagenase inhibitors

Inhibition of cytokine production

Compounds of general formula I: ##STR1## wherein: A represents the group --NH.sub.2, a substituted acyclic amine or a heterocyclic base; have collagenase inhibition activity and are useful in the management of disease involving tissue degradation and/or the promotion of wound healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumour invasion.

Hydroxamino acid based collagenase inhibitors

Hydroxamic acid collagenase inhibotors

Growing community of inventors

Cowley, United Kingdom

Michael John Crimmin