Zeneca Limited

Astrazeneca Ab

Astra Zeneca U.k. Limited

Imperial Chemical Industries Limited

Ici Pharma S.a.

Michael John Betts

Gareth Morse Davies

Michael Lingard Swain

Gloria Anne Breault

Michael Barry Gravestock

Frederic H Jung

Keith Oldham

Ian Richard Matthews

David Alan Griffin

David Anthony Roberts

The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:

Antibiotic compounds

Compounds of the formula (I), or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof,   

Oxazolidinone derivatives with antibiotic activity

Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is O, S or NH; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N, O and S; Q is selected from, for example, Q1 and Q2: Rand Rare independently hydrogen or fluoro; T is selected from a range of groups, for example, an N-linked (fully unsaturated) 5-membered heteroaryl ring system or a group of formula (TC5): wherein Rc is, for example, RCO&#x2014;, RSO&#x2014; or RCS&#x2014;; wherein Ris, for example, optionally substituted (1&#x2013;10C)alkyl or RC(O)O(1&#x2013;6C)alkyl wherein Ris optionally substituted (1&#x2013;10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described 

Substituted isoxazolines and their use as antibacterial agents

The present invention relates to carbapenems and provides a compound of the formula (I):or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,wherein, for example,

Isoxazoline derivatives useful as antimicrobials

The invention concerns a compound of formula (I) wherein for example R,is of the formula &mdash;NHC(&boxH;O)R,wherein R,is hydrogen, or (1-4C)alkyl; R,and R,are independently hydrogen or fluoro, R,is hydrogen, (1-4C)alkyl, halo or trifluoromethyl; R,and R,are, for example, independently hydrogen, (1-4C)alkyl, an acetylene of the formula -&equiv;-H or -&equiv;-(1-4C)alkyl, or a group of formula (IA) wherein, for example, Z is hydrogen or (1-4C)alkyl; X and Y are (1-4C)alkyl, halo, cyano, phenyl or heteroaryl; provided that X, Y and Z do not define a (2-4C)alkenyl group and provided that at least one of R,and R,is a group of formula (IA) or an acetylene of the formula -&equiv;-H or -&equiv;-(1-4C)alkyl; and pharmaceutically acceptable salts thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.

Oxazolidinone derivatives and their use as antibacterial agents

The present invention relates to carbapenems and provides a compound of the formula (I):

Piperazinonephenyloxazolidinone derivatives and their use as

The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:

The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; R.sup.4 and R.sup.5 are the same or different and are selected from hydrogen, halo, cyano, C.sub.1-4 alkyl, nitro, hydroxy, carboxy, C.sub.1-4 alkoxy, C.sub.1-4 alkoxycarbonyl, aminosulphonyl, C.sub.1-4 alkylaminosulphonyl, di-C.sub.1-4 -alkylaminosulphonyl, carbamoyl, C.sub.1-4 alkylcarbamoyl, di-C.sub.1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, C.sub.1-4 alkanoylamino, C.sub.1-4 alkanoyl(N-C.sub.1-4 alkyl)amino, C.sub.1-4 alkanesulphonamido and C.sub.1-4 alkylS(O)n- wherein n is zero, one or two: with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to --NR.sup.3 --. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

The present invention provides a compound of the formula (I) ##STR1## wherein: R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 and R.sup.4 are ortho with respect to one another wherein R.sup.3 and R.sup.4 are independently hydroxy or in vivo hydrolyzable esters thereof; the benzene ring being optionally further substituted; or a pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof.

Carbapenem antibiotic compounds

The present invention provides a compound of the formula: ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:

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Wilmslow, United Kingdom

Michael John Betts