Cree Gmbh

Know Bio, LLC

Creeled, Inc.

Lextar Electronics Corporation

Czee, Inc.

Michael John Bergmann

David T Emerson

John Adam Edmond

Kevin Haberern

Matthew Donofrio

Kathleen Marie Doverspike

James Ibbetson

Christopher P Hussell

Nathan Stasko

Joseph Gates Clark

Adam Cockrell

F Neal Hunter

Rebecca McDonald

Jesse Colin Reiherzer

Brian Thomas Collins

Hua-shuang Kong

Thomas Matthew Womble

Amber Christine Abare

Bernd P Keller

Kevin Shawne Schneider

Antony Paul Van De Ven

Amber Christine Salter

David Beardsley Slater, Jr

Ashay Chitnis

Christopher D Williams

Gerald H Negley

Nicholas William Medendorp, Jr

James Michael Lay

Hua-Shuang Kong

Jasper S Cabalu

Florin A Tudorica

Arthur Fong-Yuen Pun

Colin Kelly Blakely

David Power

Van Mieczkowski

Michael O'Loughlin

Daniel Carleton Driscoll

Katelyn P Reighard

Bennett Dean Langsdorf

Jeremy S Nevins

Winston T Parker

P Joseph DeSena, Jr

Jeremy Johnson

Kevin W Haberern

Thomas Place

Howard Dean Nordby, Jr

Eric J Tarsa

Jeffrey Carl Britt

David Clatterbuck

Peter Scott Andrews

Benjamin A Jacobson

Sung Chul Joo

Thomas Goldthwaite Coleman

Raymond Rosado

Jayesh Bharathan

Ting Li

Mark Raffetto

Scott Schwab

Iliya Todorov

Jacob Kocher

Michael Allen Pennington

Andrew Signor

Robert Allen Garner

Keenan Carlyle Brown

Francis Wong Daw Heng

Weng Cheng-Yao

Chen Guang-Yi

Arpan Chakraborty

Mark D Edmond

Sten Heikman

Bart P Reier

Ronan Letoquin

Bradley E Williams

Julio Garceran

Troy Gould

Nishant Tiwari

Yankun Fu

Aaron James Francis

Jack Vu

Nalini Gupta

Ashonita Chavan

Alan Wellford Dillon

James Seruto

Charles Draper

Pablo Cantu-Alejandro

James Ibbotson

Steven Scott Gilmore

Jay Thomas Norman

Kevin W Haberen

Jean Claude deSugny

Kevin Shawne Schnelder

David Dean Seibel

Doowon Suh

Jason Hansen

Howard Nordby

David Todd Emerson

Michael John O'loughlin

David Slater

Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.

Phototherapeutic light for treatment of pathogens

Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity. Illumination devices may be configured to communicate with networks and/or servers to provide control and/or management of phototherapy treatments.

Illumination devices for inducing biological effects

Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.

Monolithic LED chips are disclosed comprising a plurality of active regions on a submount, wherein the submount comprises integral electrically conductive interconnect elements in electrical contact with the active regions and electrically connecting at least some of the active regions in series. The submount also comprises an integral insulator element electrically insulating at least some of the interconnect elements and active regions from other elements of the submount. The active regions are mounted in close proximity to one another with at least some of the active regions having a space between adjacent ones of the active regions that is 10 percent or less of the width of one or more of the active regions. The space is substantially not visible when the LED chip is emitting, such that the LED chips emits light similar to a filament.

High voltage monolithic LED chip

An LED wafer includes LED dies on an LED substrate. The LED wafer and a carrier wafer are joined. The LED wafer that is joined to the carrier wafer is shaped. Wavelength conversion material is applied to the LED wafer that is shaped. Singulation is performed to provide LED dies that are joined to a carrier die. The singulated devices may be mounted in an LED fixture to provide high light output per unit area.

Wafer level packaging of light emitting diodes (LEDs)

Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity. Particular illumination devices are disclosed that provide safe and effective treatments for upper respiratory tract infections, including coronaviridae and orthomyxoviridae.

Devices and methods for impinging light on tissue to induce one or more biological effects, and more particularly illumination devices and related methods that may be used for intranasal delivery of irradiation are disclosed. Exemplary illumination devices may include a light guide that is optically coupled with a light source, where the light guide may be configured for insertion along one or more intranasal passageways. In this manner, the light guide may provide irradiation of light to tissues along or near the upper respiratory tract to prevent and/or treat various infections and other tissue conditions thereof. Light guides may include flexible materials with suitable dimensions and/or shapes that allow the light guides to follow variable paths of intranasal passageways during use.

Intranasal illumination devices

Oral illumination device

Growing community of inventors

Chapel Hill, NC, United States of America

Michael John Bergmann