Celgene Quanticel Research, Inc.

Agouron Pharmaceuticals, Inc.

Quanticel Pharmaceuticals, Inc.

Avira B.v.

Pfizer Corporation

Michael John Bennett

Jeffrey Alan Stafford

James Marvin Veal

Amogh Boloor

Stephen W Kaldor

Juan Manuel Betancort

Min Teng

Sacha Ninkovic

Yong Wang

Suzanne Pritchett Benedict

Fen Wang

Jinjiang Zhu

Eugene Yuanjin Rui

Valeri Savvateev

Michael Brennan Wallace

Toufike Kanouni

Pei-Pei Kung

Jerry Jialun Meng

Luke Raymond Zehnder

Noah Kindler

Gregory Dean

Saman Sedighian

Yuanjin Rui

Juan Manual Betancort

Juan Manuel Bettancort

Amogh Bloor

Buwen Huang

The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

Bromodomain inhibitors

The present disclosure relates to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease.

Therapeutic compounds

Various embodiments of a system, method and computer program product for normalizing data obtained from a plurality of social networks coupled to a network such as the Internet are disclosed. The system may include an interface adapted to access information from a plurality of social networks. The information that is obtained from each social network may include personal information about with the user as well as social graphs of the user that map the user to his or her friends. A data analyzer may be provided to compare the personal information obtained from the plurality of social networks to determine a normalized set of personal information for the user. The data analyzer may also compare the social graphs to determine a normalized set of friends associated with the user.

System, method and computer program product for normalizing data obtained from a plurality of social networks

Embodiments of the present invention provide a third-party system that allows parents or authorized guardians to continually grant permissions to several websites and online services and provides a one-time-authentication process of the parent-child relationship. Through this system, the need to re-authenticate the parent-child relationship or for each online company to build their own authentication system and COPPA record keeping mechanisms can be reduced or eliminated. In addition, the embodiments provided herein may afford a service for managing COPPA compliance that is relatively easy for online companies to integrate into their online services and websites.

System and method to facilitate compliance with COPPA for website registration

Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R, Rand Rare as defined in the specification) pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions such as cancers. The current invention relates to the making and using of such compounds.

Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy

Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R, Rand Rare as defined in the specification) pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions such as cancers.

Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R, Rand Rare as defined in the specification)pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions such as cancers.

Growing community of inventors

San Diego, CA, United States of America

Michael John Bennett