Cancer Research Campaign Technology Limited

British Technology Group Limited

Cancer Research Technology Limited

Cyclacel Limited

National Research Development Corporation

Secure Electrans Limited

Michael Jarman

Caroline Joy Springer

Edward McDonald

Peter Martin Fischer

Paul Workman

Florence Irene Raynaud

Bernard Paul Nutley

Roger Sherwood

Thomas Connors

Richard Knox

Stuart Wilson

Gillian Anlezark

Roger Melton

Frank Friedlos

Anthony Mauger

Gerard A Potter

Ian R Hardcastle

Susan E Barrie

Allan B Foster

Chui-Sheung Kwan

Kenneth Dawson Bagshawe

Ferdinand Chan

Helen Mary Coley

Charles A Laughton

Karen J Edwards

Stephen Neidle

Grahame N Taylor

Gavin Howard

Edward Mcdonald

A data communication authentication system () and method are described. One or more locator nodes () are installable at a location (), the or each locator node () including an identifier () and a communication system () and being arranged to provide said identifier via said communication system (). The communication authentication system () is arranged to generate an authentication code for the location () in dependence on identifiers () from the one or more locator nodes at the location and is arranged to provide said authentication code on demand for inclusion in a data communication originating locally to said location ().

Data communication authentication system and method

The present invention relates to compounds of formula 1  A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.

Purine derivatives

A transaction authorization system comprises a user interface unitcapable of accepting a transaction authorization and a utility meterprovided at a location having an associated location identifier unique to the location, wherein the utility meteris arranged to communicate with the user interface unit, to obtain a transaction authorization, and to transmit an authorization request based on the transaction authorization and location identifier to obtain authorization of the transaction.

Utility metering system incorporating a transaction authorisation system

The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.

The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, wherein A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R.sup.1 NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.2 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.

Bacterial nitroreductase for the reduction of CB1954 and analogues

The present invention provides compounds of the formula (I) wherein each R.sup.1, which may be the same or different, is hydrogen, C.sub.1-4 alkyl, or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, R.sup.2 is hydrogen, C.sub.1-4 alkyl, or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH. The compounds are analogs of trimelamol which have comparable activity but enhanced stability, and are useful as anticancer agents, particularly against ovarian cancer.

Melamine derivatives for use in the treatment of cancer

A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R--NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.1 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.

Bacterial nitroreductase for the reduction of CB 1954 and analogues

Nitrogen mustard pro-drugs of the formula ##STR1## are disclosed where R is the residue of an .alpha.-amino acid RNH.sub.2 and M is a disubstituted amino 'mustard' group, useful in antibody directed enzyme pro-drug therapy in the treatment of cancer.

Drug delivery systems

Compounds of the general formula (1) ##STR1## wherein X represents the residue of the A, B and C rings of a asteroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R.sup.14 represents a hydrogen atom and R.sup.15 represents a hydrogen atom or an alkyl or alkoxy group of 1-4 carbon atoms, or a hydroxy or alkylcarbonyloxy group of 2 to 5 carbon atoms or R.sup.14 and R.sup.15 together represent a double bond, and R.sup.16 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, in the form of the free bases or pharmaceutically acceptable acid addition salts, are used for treatment of androgen-dependent disorders, especially prostatic cancer, and also oestrogen-dependent disorders such as breast cancer.

Method for preparing 17-substituted steroids useful in cancer treatment

Compounds of the general formula (1) ##STR1## wherein X represents the residue of the A, B and C rings of a steroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R.sup.14 represents a hydrogen atom and R.sup.15 represents a hydrogen atom or an alkyl or alkoxy group of 1-4 carbon atoms, or a hydroxy or alkylcarbonyloxy group of 2 to 5 carbon atoms or R.sup.14 and R.sup.15 together represent a double bond, and R.sup.16 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, in the form of the free bases or phannaceutically acceptable acid addition salts, are useful for treatment of androgen-dependent disorders, especially prostatic cancer, and also oestrogen-dependent disorders such as breast cancer.

17-substituted steroids useful in cancer treatment

Pyridyl-propan-2-yl esters of 1-adamantane carboxylates

Substituted 1,1,2-triphenylbutenes and their use in the treatment of

2,6-dioxopiperidine derivatives, their preparation and pharmaceutical

Growing community of inventors

London, United Kingdom

Michael Jarman