Life Technologies Corporation

Michael Janes

Kyle R Gee

Shih-Jung Huang

Aleksey Rukavishnikov

Wenjun Zhou

Daniel Beacham

Upinder Singh

Hee Chol Kang

Iain Johnson

Judith Berlier

Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.

Fluorogenic pH-sensitive dyes and their methods of use (II)

Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.

Use of novel coumarins as glutathione and thiol labels

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Eugene, OR, United States of America

Michael Janes