Dow Corning Corporation

Sanofi-a Ventis Deutschland Gmbh

Michigan Molecular Institute

Dendritech Inc.

Other

University of South Australia

Michael James Owen

Susan Victoria Perz

Petar Radivoj Dvornic

Michael A Lutz

Agnes M deLeuze-Jallouli

Toshio Suzuki

Qian Jane Feng

Kenneth Michael Lee

Dominique M Freeman

Daniel Graiver

Robert Jones

Steven A Snow

Christopher Dryer

Stephen Ross Clarke

Janis Gunars Matisons

David Cullen

Dirk Boecker

Jin Hu

Robert E Kalinowski

Douglas R Swanson

William Neal Fenton

Lajos Balogh

Malcolm David MacLeod

Ralph Spindler

Agnes M De Leuze-Jallouli

Malcolm MacLood

Scott Daniel Reeves

William Carlson

Paul Lane Parham

William Carlsen

Dirk Boccker

A device is provided for use with a tissue penetrating system and/or a metering device for measuring analyte levels. The device comprises a cartridge and a plurality of analyte detecting members mounted on the cartridge. The cartridge may have a radial disc shape. The cartridge may also be sized to fit within the metering device. The analyte detecting members may be optical system using fluorescence lifetime to determine analyte levels. In one embodiment, the device may also include a fluid spreader positioned over at least a portion of the analyte detecting member to urge fluid toward one of the detecting members. A plurality of analyte detecting members may be used. Each analyte detecting member may be a low volume device.

Method and apparatus using optical techniques to measure analyte levels

Silicon containing multi-arm star polymers

The adhesion of cured polyolefin compositions to a variety of substrates is improved using as the adhesion promoter the combination of 1) an organic or organosilicon compound containing at least one epoxy group and 2) at least one compound containing a) at least one silanol or carbinol group or a hydrolyzable silanol group precursor, and b) at least one group that reacts during curing of the polyolefin.

Curable polyolefin compositions containing organosilicon compounds as

Higher generation radially layered copolymeric dendrimers having a hydrophilic poly(amidoamine) or a hydrophilic poly(propyleneimine) interior and a hydrophobic organosilicon exterior are prepared by first reacting a hydrophilic dendrimer having --NH.sub.2 surface groups with an organosilicon compound, and then hydrosilating the resulting copolymeric dendrimer with another organosilicon compound in the presence of a noble metal catalyst. In an alternate embodiment, the radially layered copolymeric dendrimers are prepared by reacting a hydrophilic dendrimer having --NH.sub.2 surface groups directly with an organosilicon dendron or organosilicon hyperbranched polymer.

High generation radially layered dendrimers

The presence in curable polyolefin compositions of a moisture curable organosilicon compound containing at least one alkenyloxy group bonded to the silicon atoms improves the adhesion to a variety of substrates that is developed during the curing reaction of polyolefin compositions cured by a hydrosilation reaction. The organosilicon compound is preferably a reaction product of ingredients comprising 1) a silane or bis-silylalkane containing at least three silicon-bonded moisture-reactive groups per molecule and 2) an organic compound containing at least one carbinol group and at least one ethylenically unsaturated group.

A process for manufacturing high molecular weight, alternating polysiloxane copolymers, by solid-liquid phase, nonaqueous, interfacial polymerization. The copolymers consist of alternating siloxane repeating units of the (AB).sub.m type, such as diphenylsiloxane units and dimethylsiloxane units, alternately polymerized together to form the copolymer. The solid-liquid phase interfacial polymerization process is fast, proceeds smoothly at room temperature, and is not reversible, i.e., no cyclic siloxane species are generated. The resulting polysiloxanes can be formed into thermoplastic elastomers which are suitable for use as sealants, fillers, and films.

Solid-liquid phase interfacial polymerization

The present invention provides adhesion promoters for curable polyolefin compositions wherein said adhesion promoters are selected from a specified group of hydrocarbyloxy-substituted organosilicon compounds and condensation products of these compounds. At least one hydrocarbyloxy group on each silicon atom of the adhesion promoter is derived from a polyhydric alcohol containing at least two hydroxyl groups per molecule and substantially no ethylenic unsaturation.

Polyolefin compositions containing organosilicon compounds as adhesion

This invention relates to organosilicon compositions useful as adhesion promoters for curable organopolysiloxanes, said organosilicon compositions being formed by reacting (A) a polyhydric alcohol, (B) an organosiloxane containing at least one organofunctional group and one hydroxyl or hydrolyzable group per molecule and (C) a silane containing at least three hydrolyzable groups per molecule.

Adhesion promoting organosilicon compositions

Dialkali metal organosilanolate and dialkali metal organosiloxanolate salts are manufactured from cyclic siloxanes or linear silicone polymers using a heterogeneous interfacial reaction process. A stoichiometric excess of an alkali metal hydroxide such as potassium hydroxide or an alkali metal oxide as a solid or dissolved or dispersed in a compatible solvent, is prepared and used as a first phase. The cyclic siloxane or linear silicone polymer is placed in a second phase either dissolved or dispersed in another solvent which is immiscible with the first phase. The resulting silanolate and siloxanolate salts can be used as monomers for solid-liquid phase and liquid-liquid phase interfacial polymerization or in a polycondensation process for the synthesis of alternating siloxane polymers. They can also be used as ring opening initiators for the base catalyzed polymerization of cyclic siloxanes.

Method of making dialkali metal silanolates and siloxanolates

Dendritic polymer based networks consisting of well-defined hydrophilic and oleophilic (i.e., hydrophobic) domains, are capable of performing as nanoscopic sponges for electrophilic guest moieties such as (i) inorganic and organic cations; (ii) charged or polarized molecules containing electrophilic constituent atoms or atomic groups; and (iii) other electrophilic organic, inorganic, or organometallic species. As a result of such performance, the networks yield novel nanoscopic organo-inorganic composites which contain organosilicon units as an integral part of their covalently bonded matrix.

Dendrimer-based nanoscopic sponges and metal composites

Dendrimer-based networks are prepared from copolydendrimer precursors having well defined hydrophilic polyamidoamine (PAMAM) or polypropyleneimine (PPI) interiors, and organosilicon outer layers ending with .tbd.Si--OCH.sub.3 surface groups. These networks have precisely controllable size, shape, and spatial distribution, of nanoscopic hydrophilic and hydrophobic domains. Such constructs are prepared by crosslinking one type of copolydendrimer precursor, or by crosslinking mixtures of different copolydendrimers having different generations of PAMAM or PPI dendrimers in the interior, surrounded by different organosilicon exteriors. Crosslinking can be controlled by adding difunctional, trifunctional, or polyfunctional low molecular weight or oligomeric crosslinking agents; or by exposing a copolydendrimer having hydrolyzable surface groups to atmospheric moisture. Elastomeric dendrimer-based networks have low glass temperatures of -15.degree. C. or below, are optically clear, transparent, colorless; and have a non-stick surface which can be formed into films of small thickness.

Dendrimer-based networks containing lyophilic organosilicon and

Radially layered copoly-dendrimers having unusual surface properties and novel applications have been synthesized and characterized. These are the first copolymeric dendrimers composed of a hydrophilic poly(amidoamine) (PAMAM) interior with hydrophobic organosilicon surfaces. These dendrimers have been prepared by surface modifications of an ethylene diamine core PAMAM dendrimer with (3-acryloxypropyl)methyldimethoxysilane, (3-acryloxypropyl)bis(vinyldimethylsiloxy)methylsilane, (3-acryloxypropyl)tris(trimethylsiloxy)silane, chloromethyltrimethylsilane, and chloromethyldimethylvinylsilane, to varying degrees of surface coverage. The obtained products were characterized by .sup.1 H, .sup.13 C, and .sup.29 Si NMR, and by DSC and TGA. The dendrimers with less completely covered organosilicon surfaces are water soluble, and have considerable surface activity, the best of which lowered the surface tension of water to less than 30 mN/m. Areas in their surface, according to the Gibbs adsorption isotherm, are surprisingly small, i.e., of the order of 100 .ANG..sup.2 /mol. More completely hydrophobed dendrimers are water insoluble, and form spread monolayers on water, capable of sustaining surface pressures over 40 mN/m. Areas per molecule are in the 1,000 .ANG..sup.2 /mol range.

Radially layered copoly (amidoamine-organosilicon) dendrimers

A zwitterionic composition useful as a surface active agent in aqueous solutions. Said composition represented by the general formula

Zwitterionic polysiloxane compositions

The invention relates to novel compositions of organofunctional betaine modified siloxanes having the general formula: ##STR1## wherein each R.sup.a and R.sup.b are lower alkyl groups, R.sup.c and R.sup.d are lower alkylene groups, x ranges from 1-4, and z ranges from 1-4. The compositions of the invention exhibit surfactant properties in that they are effective in lowering the surface tension of water. The invention also regards the process by which these modified siloxanes are made.

Growing community of inventors

Midland, MI, United States of America

Michael James Owen