Unilever Home and Personal Care Usa, Division of Conopco, Inc.

Unilever Home & Personal Care USA

Michael James Barratt

Carol Annette Bosko

Bijan Steven Harichian

Jose Guillermo Rosa

John Steven Bajor

Judith Kerschner

Yan Zhou

Arthur Ray Love

Prem Chandar

Michael Tallman

Pushker Sona

Victor De Florio

Ramesh Surianarayanan

Bian Harichian

Disclosed is a coumarin derived compound of formula (I) as skin lightening agent alone or in combination with other skin benefit agents and together with a cosmetic vehicle: 

Skin lightening agents, compositions and methods

Compounds of formula I, process for making same, and cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Where each Aand/or Aindependently is =H or COR, COR, CONHR, the latter three having the following formula A: where R=C-Csaturated or unsaturated, linear or branched, hydrocarbon; and and where R=C-Csaturated or unsaturated, linear or branched, hydrocarbon;

Disclosed are extracts ofas cosmetic skin benefit agents, preferably as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle. The inventive extracts, compositions and methods have effective skin lightening properties, may be easier to deliver to the skin, and are commercially available or cost-effective and available in nature.

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Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both Rand/or Rrepresents hydrogen (H); linear or branched, saturated or unsaturated C-Calkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; andRrepresents linear or branched, cyclic or acyclic, saturated or unsaturated C-Calkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; andRrepresents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C-Calkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R, Rand Rrepresent H, while Rrepresents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

A high skin friction cosmetic composition that can provide the consumer-desired sensory properties of traditional vanishing creams, stable at low pH, containing solid asymmetric particles and an anionic emulsifier having pKa values of less than about 4.5. The composition preferably further includes an acidic skin benefit agent. A method of controlling or preventing an oily skin appearance and/or feel especially in the facial area, by applying to the skin the inventive composition is also disclosed.

Low pH, high skin friction cosmetic creams

Cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents:Wherein X represents Carbon, Nitrogen, Sulfur or Oxygen;

Cosmetic compositions containing organic sunscreens along with a 4-substituted resorcinol derivatives of general formula I exhibit improved storage stability and oxidative stability:where each Rand R, independently, represents a hydrogen atom, &#x2014;CO&#x2014;R (acyl group), &#x2014;COO&#x2014;R CONHR; where R represents saturated or unsaturated, linear, branched or cyclic C-Chydrocarbon groups; andRrepresents (1) an alkyl group, having from 1 to 18 carbon atoms, preferably having from 2 to 12 carbon atoms, with or without substitution of one or more hydrogen atoms of a linear alkyl group with a methyl or ethyl group; e.g., Rconstitutes linear or branched chain alkyls, or (2) a group of the general formula formula (II)Where X is preferably H, n is 0 to 3 and the dashed lines represents an optional double bond.

Stabilization of sunscreens in cosmetic compositions

Cosmetic compositions containing a micronized metal oxide along with a 4-substituted resorcinol derivatives of the general formula I exhibit improved storage stability:

Stabilization of resorcinol derivatives in cosmetic compositions

Cosmetic compositions containing terpenoids along with a 4-substituted resorcinol derivative exhibit improved storage stability and oxidative stability.

Stabilization of terpenoids in cosmetic compositions

Cosmetic methods of skin lightening using coumarin derivatives of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle:Where each or both Rand/or Rrepresents hydrogen; linear or branched C-Calkyl, alkenyl, cycloalkyl, cycloalkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups;

Growing community of inventors

Oak Ridge, NJ, United States of America

Michael James Barratt