Sri International

University of California

Dh Technologies Development Pte. Ltd.

Renishaw Diagnostics Limited

Michael J Vestel

Joseph R Stetter

Erkinjon G Nazarov

Gregory W Faris

Christopher E Holland

Alexander Hallock

Lawrence H Dubois

Stephen L Coy

Karen Marie Nashold

Gareth S Dobson

Michael Coggiola

Roger H Schmidt

Daryl Oshatz

Caterina Netti

Richard Copeland

Diane P Walter

Optical microneedles are adapted for near-infrared or mid-infrared in vivo spectroscopic sensing; and provide a MEMS-based spectrometer for continuous lactate and glucose monitoring by means of a near-infrared or mid-infrared optical microneedle array in a transdermal patch.

Optical microneedle-based spectrometer

Detecting and identifying ions using surface enhanced Raman spectroscopy (SERS) and an ion separation pre-filter, such as an ion spectrometer, are provided. The combination of an ion separator as a pre-filter for SERS provides a highly sensitive detector with very low false alarm rates. Target ions from an ionized sample are identified and separated by the ion separator. The target ions are steered and deposited onto a SERS substrate for Raman spectroscopic analysis with an optical probe. The Raman spectrum is compared with reference spectra and the composition of the sample is identified. The ion current from the target ions can also be measured, preferably concurrently with the Raman spectrum measurement. Types of ion separators include a differential ion mobility spectrometer, an ion mobility spectrometer, or a mass spectrometer.

Surface enhanced Raman spectroscopy detection with ion separation pre-filter

An apparatus comprising a shape memory alloy is configured as a ring shaped sample holder for a transmission electron microscope and imparts uniform biaxial strain on a thin film mounted within. The sample holder responds to a change in temperature by changing the inner diameter, which imparts biaxial strain. In other embodiments, the sample holder is configured to change the inner diameter and change the strain on a thin film reversibly and repeatedly. In further embodiments, the sample holder is non circular. In still further embodiments, the apparatus is configured as a prime mover of a reversible radial actuator. Methods for making and using the apparatus are included in other embodiments.

Method and apparatus for adjustably induced biaxial strain

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Menlo Park, CA, United States of America

Michael J Vestel