Millipore Corporation

Other

Michael J Steuck

Aldo M Pitt

Malcolm G Pluskal

James M Coull

Alex Garfield Bonner

David Wang

Hubert Koester

Darryl J Rappin

A composite, porous membrane is formed from a porous polymer membrane having desired bulk properties on which is directly coated a cell attachment and/or growth promoting composition and a cross-linked polymer having desired surface properties. The composite membrane retains the porosity of the porous polymeric membrane. In one embodiment, when the substrate is polytetrafluoroethylene the composite is microscopically transparent.

Porous membrane having hydrophilic and cell growth promotions surface

A membrane suitable for immobilizing peptides and proteins is disclosed. The membrane is a flexible, polymeric, porous membrane which contains functional groups capable of covalently linking the peptides and proteins. The functional groups can be provided by reacting the membrane itself or a coating thereon with nucleophiles which provide --NH.sub.2, --SH, --OH or --COOH functionality to the membrane surface. Additionally, surfaces containing --NH.sub.2 groups can be further reacted with diisothiocyantes to provide an isothiocyanate functionality having enhanced covalent binding characteristics.

Membranes for solid phase protein sequencing

A hydrophobic material having a crosslinked, cationic charge-modifying coating such that the majority of the ion exchange capacity of the material is provided by fixed formal positive charge groups is disclosed. The material is produced by contacting a hydrophobic substrate with a mildly alkaline, aqueous organic solvent solution into which has been dissolved a cationic charge-modifying agent. The charge-modifying agent comprises a water soluble, organic polymer having a molecular weight of greater than about 1000, wherein the polymer chain contains both fixed formal positive charge groups and halohydrin groups. Materials of the type described herein can be used in a variety of applications including macromolecular blotting and filtration.

Charge-modified hydrophobic membrane materials and method for making the

A composite porous membrane is formed from a porous polymeric membrane having desired bulk properties on which is directly coated a cross-linked polymer having desired surface properties. The composite membrane retains the porosity of the porous polymeric membrane. The cross-linked surface polymer is produced from a crosslinkable monomer or polymer by energy from an electron beam in the absence of a chemical polymerization initiator.

Membrane having hydrophilic surface

A composite, microscopically transparent, porous membrane is formed from a porous polytetrafluoroethylene membrane having desired bulk properties on which is directly coated a cross-linked polymer having desired surface properties. The composite membrane retains the porosity of the porous polymeric membrane.

Transparent porous membrane having hydrophilic surface and process

A composite porous membrane is formed from a porous polymeric membrane having desired bulk properties on which is directly coated a cross-linked polymer having desired surface properties. The composites membrane retains the porosity of the porous polymeric membrane. A preferred composite porous membrane is formed from a porous polyvinylidene fluoride to which is directly coated with a polymer formed of a cross-linked hydroxyalkyl acrylate.

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North Reading, MA, United States of America

Michael J Steuck