Bristol-Myers Squibb Compnay

Other

Sony Electronics Inc

Wyeth

Sony Corporation

Michael J Smith

Jinbo Lee

John R Lee

Zhao-Kui Wan

Steve Yikkai Tam

David V Erbe

Kenneth W Foreman

Erhan H Gunday

Susumu Murakami

Paul Foung

Michael Doliton

Erwin P Ishmael

Nicholas A Meanwell

Jun Li

Piyasena Hewawasam

Makonen Belema

John A Bender

Omar D Lopez

Jeffrey Lee Romine

Denis R St Laurent

Gan Wang

Douglas Wilson

Van N Nguyen

Bruce Follows

Paul E Morin

Zhong Yang

Yan-Ling Zhang

Victor W Rosso

Shawn K Pack

Bin Zheng

Brian Kolaci

Ningning Xu

Ke Chen

Richard J Fox

Sergei Kolotuchin

Jianji Wang

Qi Chen

Diane Marie Joseph-McCarthy

Eric M Simmons

Peng Geng

Joerg Deerberg

Luciano Mueller

Carlos A Guerrero

Amanda J Rogers

Neil A Strotman

Michael Dummeldinger

Weixin Xu

Michael L Baron

Eva Deanna Binnun

Daniel S Treitler

Tamas Benkovics

Dimitri Skliar

Steven J Kirincich

Dong Lin

Maxime C D Soumeillant

Bahar Inankur

Candice Lee Joe

Jerome D Goldfischer

Harshkumar Patel

David Thomas George

Yichen Tan

Shane Mckenna

John A Easter

Bao-Ning Su

Jason Hamm

Alessandro Fabio Moretto

Jun-Jun Wu

Harold J Malone

Haiying Tang

Harvey Goldfisher

Steven Tymonko

Sergei V Kolotuchin

Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I).

Process for preparing carbamoyloxymethyl triazole cyclohexyl acid compounds

Deuterated polymer-biomolecule conjugates and the synthesis and use of deuterated polymer-biomolecule conjugates for detecting the location of specific molecules, e.g., cell surface molecules, in a subject, and for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

Methods and compositions for deuterated biologics

The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis. 

Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide

The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Hepatitis C virus inhibitors

The present disclosure generally relates to a process for synthesizing methyl ((1S)-1-(((2S)-2-(5-(4'-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to intermediates useful in this process.

Process for synthesizing compounds useful for treating hepatitis C

This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1B (PTP1B).

PTP1b inhibitors

Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.

Inhibitors of protein tyrosine phosphatase 1B

Film transport apparatus for a cine-video system in which video signals are produced from film that is driven between supply and take-up reels. The film, which may be wound in A or B configuration on each reel, is threaded automatically about a film drive mechanism which transports the film from the supply reel, through a film gate to the take-up reel. Tensioning apparatus imparts tension to the film at the entry and exit of the film gate which, during the threading operation, causes the respective reels to rotate before film actually is transported therebetween. The direction in which each reel rotates to unwind film therefrom when tension is imparted serves to identify whether the film is wound in A or B configuration. Advantageously, a programmable processor controls the film transport speed in response to a user-actuated knob; and this same processor serves to detect when the film approaches its end on the supply or take-up reel.

Cine-video film transport apparatus having film supply and take-up reels

Cine-video film transport apparatus

A technique for providing automated direction and guidance to nurses to assist in the task of dispensing medication to patients. Information on all patients is stored in a stationary base computer. Information pertinent to the medication dispensing task is transferred from the base computer to a portable, hand-held computer adapted to be carried by the nurse during rounds. One portable computer contains information for only those patients assigned to one nurse. As the nurse approaches a patient, the portable computer is activated to display the name of each medication to be dispensed to that patient along with dose, route, and comments. The nurse enters into the portable computer whether the medication was dispensed or not. It can, thus, be determined whether any medication remains to be dispensed, and why it has not yet been administered. At the completion of rounds, data is transferred from the portable computer to the base computer to update the information stored in the base computer.

Computerized dispensing of medication

Growing community of inventors

Somerset, NJ, United States of America

Michael J Smith